Get

In Your Inbox

Catster is reader-supported. When you buy via links on our site, we may earn an affiliate commission at no cost to you. Learn more.

Shots For Unvaccinated Cats & Older Kittens: 2025 Guide (Vet Answer)

vet holding cat for vaccination

Cats require vaccinations to help protect them from common infectious diseases. Determining which vaccinations your cat may need can be stressful. In this article, we will discuss vaccinations available to our feline companions and recommended vaccine protocols. The American Animal Hospital Association1 and American Association of Feline Practitioners have developed guidelines often followed in the United States.2 It is important to note that vaccination requirements may vary based on your country, disease prevalence, and your pet’s lifestyle so always contact a veterinarian for their specific recommendations.

divider cat paws 2 oct 2024

The 5 Common Shots for Unvaccinated Cats and Older Kittens

1. Rabies

The rabies vaccination is required by law in many states and is considered a core vaccination. Kittens typically receive this vaccination between 12–16 weeks of age, but the age of vaccination is dependent on state laws and manufacturer guidelines.

After the initial vaccination is administered to a kitten or a cat with an unknown vaccine history, another rabies shot should be administered 1 year later. After this next vaccination, the rabies will need to be given every 1–3 years, depending on local law and the type of vaccination administered. Wildlife can serve as a potential reservoir for this virus, and once contracted, the disease is fatal.

cat-having-a-vaccine
Image Credit: Africa Studio, Shutterstock

2. FVRCP (Feline Distemper, FRCP, FVRCPP)

This combination of vaccinations helps protect cats against several different viral respiratory and gastrointestinal pathogens and is considered a core vaccination. The vaccination offers protection against feline viral rhinotracheitis (herpes), calicivirus, and panleukopenia (parvovirus). It is initially given in a series to kittens.

The vaccination can be given starting at 6 weeks and is then boosted every 3–4 weeks until the kitten is over 16 weeks of age. In adult cats without a history of vaccination, the vaccination is administered in a two-part series given close to 3 weeks apart. After the completion of the initial series, a kitten can receive an additional vaccine at 6 months, or at 1 year of age. Further vaccinations are administered every 1–3 years, depending on the vaccine type.


3. Feline Leukemia

Feline leukemia is a highly contagious virus that can cause immune suppression and cancer in affected cats. This vaccine is considered a core vaccine in kittens but is considered a non-core vaccine in adult cats, depending on their lifestyle.

This virus is most common in outdoor cats that have close interactions with other cats. It is also administered in a two-part series and then boosted 1 year later. This can be given to cats as young as 8 weeks of age. For cats that are going to have access to the outdoors or live in an environment where there is the risk of exposure to the virus, the vaccination can be continued. The frequency of revaccination will depend on the risk of exposure and the type of vaccine administered.

cat vaccination
Image Credit: YULIYA Shustik, Shutterstock

4. Feline Chlamydophila Disease

A vaccination against the bacterial agent Chlamydophila felis is available for cats with a high likelihood of illness. This bacterial pathogen can cause conjunctivitis and rhinitis, typically in young cats. The vaccination can be administered to kittens or adults without a vaccination history and should be administered according to the product label. This is considered a non-core vaccination and is only used in environments in which infection with chlamydia has been confirmed.


5. Bordetella

An uncommon, non-core vaccination available to cats is the Bordetella vaccination. Bordetella is an upper respiratory pathogen that can be spread amongst cats. The vaccination doesn’t offer complete protection but may be beneficial in environments where Bordetella has been confirmed. This attenuated live vaccination is given intranasally and should be administered according to the product label.

cat vaccination
Image Credit: YULIYA Shustik, Shutterstock

divider cat paws 2 oct 2024

Side Effects of Vaccinations

Following vaccination, cats may experience soreness, fever, and lethargy. On occasion, localized swelling may be noted. It is encouraged that reactions that occur following vaccination administration be reported to a veterinarian. In some situations, more serious hypersensitivity reactions may occur including anaphylaxis.

Injection site sarcomas can occur because of inflammation following injection. Fortunately, this is not a common occurrence since non-adjuvanted vaccinations have become more readily utilized. Sarcoma formation is still a possibility, and as a result, most veterinarians will administer vaccinations in a location that can allow for surgical removal if a sarcoma were to develop.

If you are concerned or have questions about your cat’s health, you can also speak to a vet from the comfort of your own home to help make a plan. They can determine when an in-clinic vet visit should be made.

If you need to speak with a vet but can't get to one, head over to PangoVet. It's an online service where you can talk to a vet online and get the advice you need for your pet — all at an affordable price!

PangoVet_Mention-in-Content for PangoVet2 save money

Important Notes

It is critical to note that there are several different ways a vaccine is structured. For example, cat vaccines can be inactivated, recombinant, or attenuated live. Additionally, the routes of administration can also vary. As a result, vaccination protocols may differ depending on the product used. It is important to speak directly with a veterinarian regarding the vaccinations that they carry and their recommended dosing protocols.

divider cat paws 2 oct 2024

Conclusion

Vaccinations are at the core of preventative care. A veterinarian will be able to help guide you as to which vaccinations your cat should receive. This will be determined by the age of your cat and your cat’s lifestyle. It is imperative to note that no vaccination can offer 100% protection against illness; however, vaccinations can significantly reduce signs of illness.


Featured Image Credit: bmf.foto.de, Shutterstock

Want content like this delivered to you?

Sign Up For Our Newsletter

News, insights, expert advice, and everything cat

* By submitting, you agree to our Terms & Conditions and Privacy & Cookies Policy.

How useful was this post?

Click on a star to rate (you can leave written feedback after clicking submit)

Help us improve Catster for pet parents!

Your feedback really matters.

What did you like about this post? Also how can we improve it?

Join the conversation

Leave a Reply

You’re very welcome to leave a comment or question. Please know that all comments must meet our community guidelines, and your email address will NOT be published. Let’s have a positive and constructive conversation.

Talk With A Vet Online

Peace of mind,
anywhere, anytime

Affordable vet advice

Is It True That Most Cats Have Green Eyes? Vet-Reviewed Facts & FAQ

Eyes may be the window to the soul, but in cats, those windows come in many colors. If you’ve ever wondered if it’s...

Grey Sphynx Cat: Info, Pictures, Care & Traits

Everything about the grey Sphynx cat screams for attention, starting with the animal’s hairless appearance. Relatively big ears and eyes also complete the...

29 Best Gift Ideas for Cats in 2025 – Reviews & Top Picks

Gift-giving season is always a bit nerve-wracking, largely due to the possibility that you might end up buying the wrong gift or even...

How Long Do Maine Coon Cats Live? Vet-Verified Lifespan & FAQ

Considered the largest of domestic cat breeds, the Maine Coon holds a special place in the hearts of feline lovers worldwide. They tend...

More related

We Chat With Former Pro Drag Racer Ashley Force Hood About Cats and Cars

Growing up we remember being a fan of the Sammy Hagar song “I Can’t Drive 55.” Of course, then Sammy joined Van Halen...

Cat’s Life Saved Twice: Garbanzo Gets a New Lease on Life (with Video)

Every now and then, you come across a story that hits you right in the feels, and this week, that story is all...

Are Savannah Cats Legal in Massachusetts? Facts & FAQ

The Savannah Cat is a domestic cat breed that was originally bred from a Serval cat, which is a type of wild cat...

150 Great Names for Cornish Rex Cats: Our Favourite Names For These Beauties

Cornish Rex cats are one of the most unique breeds and resemble curly-haired pixies! Because of the tightly curled coats and impish nature...

Keep reading

Why Do Cats Fight? 8 Vet-Verified Reasons & How to Stop the Fighting

If you live in a multi-cat household, you may be familiar with spats among your feline friends. Referred to as inter-cat aggression, cat fights are stressful to pet parents and potentially harmful to the cats. In this article, we explore...

two cats fighting

Do Cats Need to Fast Before Having Surgery? What You Need to Know!

When a cat needs surgery, owners have several questions about how they can prepare them for the upcoming procedure. One of the most common questions is about fasting before surgery. In short, cats typically do need to fast before surgery...

cat and owner and vet

Will a Cat Eat Rat Poison? How to Use It Safely Around Them

Everyone has heard the old adage that curiosity killed the cat, but anyone who’s spent time around cats knows just how dangerously curious they can be. Cats lack the same type of self-preservation that humans have, which often leads them...

Poison for mice in a cardboard box

IAMS Cat Food Review 2025: Pros, Cons, Recalls, & Verdict

As cat owners, we always strive to give our beloved furry family members the best. Unfortunately for some of us, our budget doesn’t always align with the top-tier food options. However, you don’t want to pick any old food you...

IAMS Cat Food Review

Does Catnip Help a Cat in Heat? Vet-Reviewed Facts & FAQ

There are a lot of old wives’ tales out there about how to deal with a cat in heat. One of the most traditional solutions is giving catnip. But does it actually work? Catnip is a member of the mint...

cat-eating-catnip

Why Is My Kitten Not Eating? 8 Vet Reviewed Possible Reasons

It’s always exciting to get a new kitten. By nature, kittens are playful, inquisitive, and somewhat fussy creatures with an independent streak that cat lovers find endearing. While you probably bought top-quality kitten food and were looking forward to watching...

little kitten sitting by a bowl of milk

Why Does My Cat Try to Bury Her Food? 3 Vet-Reviewed Reasons for This Behavior

Domestic cats sometimes act a little strange. Whether having a five-minute case of the zoomies or refusing to come out and meet your friend who popped by to say hi, it can be hard to predict what our cats will...

cat caching

How Long Do Outdoor Cats Live?? Average Lifespan & Info (Vet-Approved)

Under natural conditions, cats are potent predators that effectively stalk and capture prey in a variety of outdoor environments. However, cats have become domesticated in the last 10,000 years, and in modern times, the number of domesticated cats exponentially outnumbers...

Polydactyl orange tabby cat walking outdoor