Get

In Your Inbox

Catster is reader-supported. When you buy via links on our site, we may earn an affiliate commission at no cost to you. Learn more.

Buprenorphine for Cats: Usage, Dosage & Side Effects (Vet Answer)

young woman giving cat a tablet pill

Buprenorphine is a prescription-only drug that can be used for pain relief in cats. It belongs to a class of drugs called opioids, which provide very strong pain relief. In comparison to other opioid drugs, cats seem to respond well to buprenorphine and receive the benefits without experiencing many unwanted side effects.

In many countries, the use of buprenorphine is classed as “off-label.” This simply means that the medication is prescribed for use in a way that is not described on the medication label. Vets often prescribe medications this way and it is perfectly safe. There are some potential side effects of the use of buprenorphine in cats, but they are relatively rare.

Not all cats are good candidates for the use of buprenorphine. This does depend on their circumstances including any ongoing health issues. Your vet will be able to advise you on whether it can be safely used on your cat.

divider 3 paws

What Is Buprenorphine for Cats?

Buprenorphine is mainly used for pain relief in cats. It can be used to manage pain from surgical procedures such as neutering, fracture fixation, the repair of wounds, and dental procedures.

It is often used to manage chronic pain, for conditions such as arthritis. It can also be used for acute pain relief for trauma, injuries, or other painful situations where deemed necessary. In some cases, it is used to help cats that experience feline lower urinary tract disease (FLUTD). Buprenorphine can also be used as part of a pre-medication drug combination to give to cats before surgical procedures.

Buprenorphine is a DEA Schedule III controlled drug.1 This means there are strict rules around the prescribing and dispensing of the drug. It is illegal for owners to use, sell, or give the drug to any human or animal that it has not been prescribed for. In no circumstances should drugs prescribed for humans be given to cats or vice versa.

Buprenorphine should be stored at room temperature between 20°C and 25°C (68°F and 77°F). It should always be kept out of direct sunlight and excessive heat. It should be kept in a locked container as it is a controlled drug.

Always ensure only authorized personnel have access to Buprenorphine, and always keep out of the reach of children and animals.

woman giving cat a pill
Image Credit: New Africa, Shutterstock

How Is Buprenorphine Given?

There are a few different ways buprenorphine can be given to cats. Your vet will typically inject it when your cat is a patient in a veterinary hospital. The injection can be administered either subcutaneously, (under the skin) into the muscle or straight into the vein.

Buprenorphine is also available in the form of a transdermal patch, and can also be given orally in liquid form. It is not eaten as such, but rather sprayed onto the mucous membranes and allowed to soak in. It is usually absorbed after being squirted under your cat’s tongue or on the pouches of their cheek. This is thought to be the best way to manage chronic pain as the drug is readily absorbed by the tissues in the mouth.

The dose is always carefully calculated by your vet and will depend on your cat’s weight. It can be given with or without food.

Doses that are given orally by owners must be measured out and checked carefully as the drug is very potent and it is easy to overdose. There is no specific monitoring required for the use of buprenorphine in cats. Owners should be aware of the potential side effects and take their cats in for regular checkups while they are taking the medication.

What Happens if You Miss a Dose?

If you realize that you have missed a dose, give the missed dose as soon as you remember. After this, continue with the recommended time between each dose. If it is close to the next due dose, you will have to miss the dose and then continue as you have been instructed on the prescription.

Never give double doses or extra doses within the specified time frame.

vet-giving-pill-to-kitten
Image Credit: Andrew Rafalsky, Shutterstock

divider 3 paws

Potential Side Effects of Buprenorphine

Typically, the most common side effect seen is drowsiness/sedation.

Other common side effects include:

Usually, unwanted side effects will disappear if the dose is reduced, or the drug is stopped completely.

An overdose of buprenorphine is rare, but it can occur. Clinical signs include excessive sedation, slower movements and lack of coordination, drooling, and slower breathing rate. If you think you may have given your cat an overdose, contact your vet immediately.

If you need to speak with a vet but can't get to one, head over to PangoVet. It's an online service where you can talk to a vet online and get the advice you need for your pet — all at an affordable price!

PangoVet_Mention-in-Content for PangoVet2 save money

Other useful resources are:

divider cat paws 2 oct 2024

Frequently Asked Questions

How long does Buprenorphine last in cats?

The duration of action does depend on the route of administration. It usually has a lasting effect ranging from 6–12 hours.

Are there alternatives to Buprenorphine for cats?

There are many alternatives for the management of pain in cats. Commonly used drugs include non-steroidal anti-inflammatory drugs such as meloxicam, other opioids such as morphine, and local anesthetics such as lidocaine. Your vet will be able to discuss which type of drug is best suited to your cat’s individual needs.

How long can cats use Buprenorphine for?

Cats are usually prescribed buprenorphine for a few days at a time. Typically, this is after surgery or an injury where the cat requires a high level of pain relief. The long-term safety of the use of buprenorphine for over 5 consecutive days has not yet fully been investigated in cats.

divider cat paws 2 oct 2024

Conclusion

Buprenorphine is a valuable drug for the management of pain in cats. It provides strong analgesia for conditions such as post-surgical pain and acute injuries. It has a long-lasting effect on cats and can be given via multiple administration routes. This provides flexibility for individual cats in different scenarios.

It is a controlled drug, and it is very potent, so care must always be taken when administering doses and using it in general.

Related Reads: 


Featured Image Credit By: New Africa, Shutterstock

How useful was this post?

Click on a star to rate (you can leave written feedback after clicking submit)

Help us improve Catster for pet parents!

Your feedback really matters.

What did you like about this post? Also how can we improve it?

Join the conversation

Leave a Reply

You’re very welcome to leave a comment or question. Please know that all comments must meet our community guidelines, and your email address will NOT be published. Let’s have a positive and constructive conversation.

Talk With A Vet Online

Peace of mind,
anywhere, anytime

Affordable vet advice

Cerenia for Cats: Uses, Doses & Side Effects (Vet Answer)

It can be highly stressful as a cat owner when your feline is sick. If your cat has a bug causing them to...

Veterinarian giving injection to cat_Africa Studio_Shutterstock

Metronidazole for Cats: Our Vet Explains the Dosage, Uses & Side Effects

Metronidazole is a common medication found on the shelves of veterinary hospitals and pharmacies. This antibiotic is used to treat several different disorders...

metronidazole antibiotic vial

What are the Side Effects of Prednisolone & Prednisone? Our Vet Explains

Glucocorticoids like prednisone and prednisolone have many useful functions in veterinary medicine. In fact, they have been prescribed as a treatment for nearly...

pile of white round tablets

Gabapentin for Cats: Uses, Doses & Side Effects (Vet Answer)

Many human drugs are also used in pets, and gabapentin is one such drug. This medicine is used in veterinary medicine as an...

nebelung cat in vet clinic

More related

infusion of liquid medicine by a veterinarian

Clavamox for Cats: Uses, Doses, & Side Effects (Vet Answer)

If you take your feline fur baby to the veterinarian because they are feeling bad, a veterinarian will probably give them an examination...

cat with pill bottle

Benadryl For Cats: Our Vet Explains Safety, Dosage & Side Effects

“Benadryl” is the brand name of an over-the-counter, human-use antihistamine drug. The active ingredient in Benadryl is diphenhydramine hydrochloride. Benadryl is used to...

Infusion of liquid medicine by a veterinarian from a syringe into the mouth of cat

Miralax for Cats: Our Vet Explains Dosages, Uses & Side Effects

You may notice your cat in the litter box, straining to defecate and being unable to. You may also notice that your cat...

vet holding a cat

Convenia for Cats: Our Vet Explains Uses, Doses, & Side Effects

If your feline friend is unwell and has an infection, your veterinarian may give them an injection of Convenia alongside other treatments. So,...

Keep reading

Blue Buffalo Cat Food Review in 2025: Recalls, Pros & Cons

Review Summary Many pet owners might be surprised to learn that Blue Buffalo was only founded in 2003. Despite being a relatively young company, Blue Buffalo has quickly carved out a name for itself as one of the premier manufacturers...

Blue Buffalo Cat Food Review

Signs a Cat is Dying: 11 Vet-Verified Changes to Look For

It’s the moment that no cat owner wants to contemplate, but as our feline friends get older or maybe develop an illness, their deteriorating health can begin to show signs your cat is dying. As difficult as this time can...

tired or sick cat

Can Cats Eat Ketchup? Vet-Reviewed Diet Facts & FAQ

When considering what kind of human foods are okay to give to our cats, we’re usually thinking in terms of actual food and not condiments, such as mayonnaise or ketchup. However, there’s always a chance our feline friends could manage...

Can Cats Eat Ketchup

Can Cats Eat Venison? Important Facts & Health Guidelines 

The word “venison” (from the Latin verb venari, meaning “to hunt”) refers to meat from large game animals, most commonly deer. Though not the most typical protein in commercial cat foods, venison is used in some food formulas. Home-prepared venison...

Can Cats Eat Venison

Why Does My Cat Attack Me at Night? 10 Vet-Reviewed Reasons

Ever wondered why your cat turns into a nighttime ninja, pouncing and attacking when you’re trying to get some sleep? It’s a mystery that many cat owners face: “Why does my cat attack me at night?” These midnight madness sessions...

cat waking up the senior man in bed

What Can Kill a Cat? 16 At-Home Items Vets Tell Us To Watch Out For

Being a cat parent is a responsibility that should be taken seriously. Your cat needs water, food, frequent litter changes, grooming, playtime, and plenty of attention. Another considerable responsibility is ensuring that your cat is healthy and safe. This means...

cat on a counter above the washing machine

Do Neutered Cats Still Mate? Vet-Approved Facts

Neutering a cat involves surgically removing a cat’s reproductive organs to prevent them from reproducing. It is done by a veterinarian by the time most cats are around 4 months of age or sexually mature. Owners may choose to get...

Close-Up Photography of Tabby Cats Laying

Can a Cat Detect Carbon Monoxide? The Interesting Answer! (Vet Reviewed)

Cats cannot smell or otherwise detect carbon monoxide. This gas is completely odorless. Therefore, there is no way for your feline to detect it—despite their stronger noses. However, cats have a higher metabolic rate than humans, as well as a...

hand holding carbon monoxide alarm