Get

In Your Inbox

Catster is reader-supported. When you buy via links on our site, we may earn an affiliate commission at no cost to you. Learn more.

Do I Need to Get My Indoor Cat Vaccinated? Vet Approved Facts & Safety Guide

Share

back-view-of-two-cats-looking-out-the-window

If your cat is an indoor cat that rarely ventures outside, their chances of injury and illness are likely lower, but does this mean they won’t need to be protected against any potential diseases?

Veterinarians recommend all cat get their core vaccines. These vaccines protect cats against widely distributed diseases that have a high mortality rate. A cat’s core vaccines are feline herpes virus vaccine 1 (FHV-1), feline calicivirus vaccine (FCV), feline panleukopenia virus vaccine (FPV), rabies, and feline leukemia virus vaccine (FeLV). Believe it or not, even your indoor cat is at risk of contracting the disease through fomites, and this is the term used for third objects that work as a transportation system for a pathogenic virus. That’s right, even if your cat does not have contact with other cats, you could certainly bring a virus home on your clothing or shoes!  

This article discusses vaccines, their pros and cons, and how you can make the best and safest decision for your cat.

divider cat paws oct 2024

Vaccine Overview

You are free to use this image but we do require you to link back to Catster.com for credit

Vaccines are one of the most controversial topics when it comes to both humans and animals, and making the right decision can be a stressful and confusing process for pet owners.

It is essential to understand that no vaccine is 100% safe, and it’s also important to be aware and acknowledge that vaccines also save lives. Vaccines are preparations of microbes, like bacteria or viruses, that have been manipulated or inactivated so that they don’t cause a disease process. By administering these vaccines to the animal, it trains the immune system to protect against the agents targeted by the vaccine.

There are two classifications of cat vaccinations: core and non-core vaccinations. Core vaccinations are recommended for all cats to protect them from common and severe conditions.

They include:
  • Rabies: Rabies kills several mammals every year, and there is no cure. Rabies vaccinations are required in most states in America.
  • Calicivirus, Feline Viral Rhinotracheitis, and Panleukopenia (FVRCP): This combination vaccine, commonly known as the distemper shot, protects against viral infection rhinotracheitis, calicivirus, and panleukopenia.
  • Type I feline herpesvirus (FHV, FHV-1): This is the leading cause of upper respiratory infections.
  • Feline Leukemia Virus (Felv): This vaccine is considered a core vaccine for kittens and young adult cats under 1 year of age. Even if it protects against a viral infection spread by close contact, if your cat typically stays inside, you never know if it will jump out or escape one day.
cat getting a shot from a vet
Image Credit: Kachalkina Veronika, Shutterstock

Non-core vaccinations are recommended for outdoor cats.

They include:
  • Feline Immunodeficiency Virus (Felv):  Also known as cat’s AIDS, this attacks the cat’s immune system and is normally spread through bites.
  • Feline infectious peritonitis (FIP): Is caused by a coronavirus and normally spread through feces.
  • Chlamydophila felis: Is a bacteria that causes respiratory disease in cats. It is normally transmitted from cat to cat, especially in crowded conditions.
  • Bordetella: This vaccine is recommended to protect your cat from the bacteria Bordetella, which can cause upper respiratory infections that are highly contagious. Your vet may recommend this if your cat is around a lot of other animals.

divider cats oct 2024

What to Consider?

Before giving your pet a vaccine, you should consider your cat’s overall health and the risk factors it is exposed to, the prevalence of disease in your area, consequences of infection, previous vaccine reaction, vaccine efficacy, duration of immunity, and vaccine properties. As you see, even indoor cats need to be protected against certain viral agents. It’s best to consult your veterinarian about your cat’s vaccination schedule and keep them up to date.

Benefits and Drawbacks of Vaccines

Vaccinating your cat can help protect it and other cats from serious diseases. It will also help protect people from diseases, such as rabies, that can be transmitted by cats.

Vaccinations can also have reactions that range from mild to severe. Every cat can react differently, but there are a few signs you can look out for.

  • Swelling: Lumps and swelling in specific areas are also common side effects. A firm bump usually develops at the injection site. It’s essential to keep an eye on it for signs of inflammation, growth, or infection. It typically passes within a week, but if it doesn’t, and it has grown or seems infected, you will need to contact your vet.
  • Lethargy and a mild fever: These signs should be mild and last only 1 or 2 days, but if it goes on longer than 2 days, you should consult your vet.
  • Cold-like signs: Some vaccines are administered through your cat’s nose or eyes, which can lead to cold-like signs, such as sneezing, coughing, and a runny nose, but it should pass within a day or two.

If your cat has a severe reaction from a vaccine, the signs will appear either straight away or up to 48 hours later. These signs include facial swelling, vomiting, diarrhea, and difficulty breathing.  Anaphylaxis is the most severe allergic reaction that pets can experience due to vaccinations, and it can be life threatening if not treated immediately.

Several studies have found a link between the FVRCP vaccine’s excessive use (hyperinoculation) and kidney inflammation. The FVRCP vaccine is made from feline kidney cells; when injected into your cat, the body recognizes them as foreign and produces antibodies.

Unfortunately, those antibodies do not distinguish between the injected kidney cells and the cat’s kidney tissue, which can result in an autoimmune attack on its kidneys. However, more research is needed to determine whether vaccines cause or contribute to feline kidney disease.

sick cat
Image Credit: sick cat, Flickr

Keeping Your Cat Safe

Vaccines can be a vital part of keeping your cat safe, and your cat is most likely to be safe from a severe vaccine reaction.

Cats are no different from humans regarding needles, so you will need to make their visit to the vet as comfortable as possible. Use a sturdy and comfortable carrier with their favorite toy or blanket so that they can recognize the smell. Cats are sensitive and can pick up on your energy, so it’s important to stay as calm as possible.

When you arrive home, provide a warm, safe space for your cat to lie down and make sure they have access to water and food. Keep checking up on your cat, ensuring they are comfortable, but also try not to disturb them too much.

Adjuvants are substances added to vaccines that cause inflammation at the injection site, alerting the immune system to the presence of the vaccine. This substance can sadly cause an aggressive tumor that can be fatal, known as sarcoma. It’s essential to ask your vet about the vaccines they are using and avoid vaccines with adjuvants.

If a cat requires two vaccines, they can be given at least 1 week apart. This allows time for the first vaccine’s inflammation to decrease before administering the second. Another valid reason for separating vaccines is that the immune system can only do so much at once.

divider cats oct 2024

Conclusion

There are many variables regarding vaccines, and your comfort level after research also plays a role in the decision. Core vaccinations for cats are highly recommended, especially rabies, since the disease can also be passed to humans, and there is no cure.

Cats that live indoors should also be protected since they could go roaming, escape, or be surrounded by other cats when visiting a grooming parlor or boarding facility. While all vaccines are not 100% safe, they also save lives, so weighing the pros and cons is vital to the decision-making process. At the end of the day, we all want to keep our pets safe, and it’s up to you as the parent to make the best-informed decision.


Featured Image credit: Yoshihide KIMUR, Shutterstock

Want content like this delivered to you?

Sign Up For Our Newsletter

News, insights, expert advice, and everything cat

* By submitting, you agree to our Terms & Conditions and Privacy & Cookies Policy.




How useful was this post?

Click on a star to rate (you can leave written feedback after clicking submit)

Help us improve Catster for pet parents!

Your feedback really matters.

What did you like about this post? Also how can we improve it?

Join the conversation

Leave a Reply

You’re very welcome to leave a comment or question. Please know that all comments must meet our community guidelines, and your email address will NOT be published. Let’s have a positive and constructive conversation.


Catster's Digital Magazine is Back!

Vet-approved health & behavior advice

Real cat stories & community features

Life Through Minnie’s Eyes: The Cat Behind the Comics

I used to volunteer at a small local cat shelter called Little Flower Rescue. I had actually met another cat, Sylvia, whom I...

The Original Space Invaders – Why Zero Respect for Personal Boundaries Is a Good Thing

Cats have a reputation for being independent, and in many ways they are. But anyone who has tried to work at a laptop...

How Cats Are Helping to Cure Cancer

When most people think about medical breakthroughs, they picture scientists in laboratories and clinical trials involving human patients. Few would imagine that the...

Ask Dr. Paola – My Cat Loves Eating Grass, But It Makes Her Vomit! (June 29, 2026)

Welcome to our “Ask Dr. Paola” series, where every Monday we bring expert advice straight from Dr. Paola Cuevas (MVZ) to help our...

More related

Why Does My Cat Lay, Sleep, or Play in the Litter Box? 6 Vet-Reviewed Reasons

It is more common than you might think to see a cat lying or even sleeping in their litter box, and it is...

8 Best Vacuums for Cat Litter in 2026 – Reviews & Top Picks

Vacuuming can be a daunting task, especially when it comes to kitty litter. Every cat owner knows that their pet can make quite...

Ragdoll Kittens for Sale in Arkansas: 2026 Breeder List

Excited Cats advocates for adopting before shopping, though we fully understand there are many reasons for seeking a breeder. So, we encourage it...

How to Get Cat Vomit Out of Carpet: Essential Tips & Tricks

It’s an unfortunate reality of owning pets; there are going to be messes that you have to clean up. Rather than get upset,...

Keep reading

What Does It Mean When a Cat Is Panting? 7 Vet-Reviewed Reasons

Panting is very common in our canine pals, but is much more rarely observed in cats. It’s important not to shrug your cat’s panting off like you do when your dog does since this can be an indication that something...

cat walking outdoor and panting

Pure Balance Cat Food Review in 2026: Recalls, Pros & Cons

Review Summary Perhaps you’ve been scouring the aisles at your local Walmart and come across a brand you’ve never heard of before. Pure Balance is a signature brand made explicitly for Walmart locations. But just because it comes from a...

Pure Balance Cat Food Review

How to Tell if Your Cat Has Diabetes: 7 Vet-Reviewed Signs to Look For

As cat owners, we want our cats to be healthy and safe. However, a cat owner must know what signs to watch out for that could suggest poor health. For instance, many cats, especially older ones, may develop diabetes mellitus....

cat_pasja1000, Pixabay

Is Pine-Sol Safe for Cats? Vet-Reviewed Health Facts

Most cat owners are aware of the harmful effects that pine oil can have on cats and avoid using products that contain it. Pine-Sol is a popular multi-surface cleaner, and while it still does have “pine” in its name, most...

Catster_Is Pine-Sol Safe for Cats

5 Best Litter for Cats with Asthma in 2026 – Reviews & Top Picks

It can be tough to parent a cat with asthma, particularly because of cat litter. The tiny particles and dust that get kicked up when a cat litter box is being cleaned can really affect asthma-suffering cats. Many people therefore...

kitten in the litter box

Can Cats Eat Yogurt? Vet-Reviewed Nutrition Facts & FAQ

For many, thinking of cats brings up images of them lapping up a saucer of milk. While it’s safe for kittens to have their mother’s milk, older cats are lactose-intolerant, so giving them milk or yogurt could result in a...

Can Cats Eat Yogurt

Are Polydactyl Cats Inbred? Vet Approved Facts & FAQ

Cats have various physical traits that make them unique. For example, some cats are short and squat, while others are long and slender. Some have big eyes, while others have small eyes. Some have long tails, while others have short...

polydactyl shy cat orange

Will Fleas Kill a Kitten? Facts & Safety Guide

Pet owners know fleas are an itchy nuisance, but the parasites can cause even bigger issues for some animals, such as kittens. Fleas bite to feed, and their food is your pet’s blood. A heavy flea infestation could result in...

kitten wearing green flea collar

Love Cats? So Do We! Join the Catster Community

Stay informed with expert pet care insights delivered straight to your inbox! Discover professional guidance on animal behavior, feeding tips, trusted product picks, and much more.




Sign up for the Catster Email Newsletter

Stay informed with expert pet care insights delivered straight to your inbox! Discover professional guidance on animal behavior, feeding tips, trusted product picks, and much more.