Get

In Your Inbox

Catster is reader-supported. When you buy via links on our site, we may earn an affiliate commission at no cost to you. Learn more.

Do I Need to Get My Indoor Cat Vaccinated? Vet Approved Facts & Safety Guide

back-view-of-two-cats-looking-out-the-window

If your cat is an indoor cat that rarely ventures outside, their chances of injury and illness are likely lower, but does this mean they won’t need to be protected against any potential diseases?

Veterinarians recommend all cat get their core vaccines. These vaccines protect cats against widely distributed diseases that have a high mortality rate. A cat’s core vaccines are feline herpes virus vaccine 1 (FHV-1), feline calicivirus vaccine (FCV), feline panleukopenia virus vaccine (FPV), rabies, and feline leukemia virus vaccine (FeLV). Believe it or not, even your indoor cat is at risk of contracting the disease through fomites, and this is the term used for third objects that work as a transportation system for a pathogenic virus. That’s right, even if your cat does not have contact with other cats, you could certainly bring a virus home on your clothing or shoes!  

This article discusses vaccines, their pros and cons, and how you can make the best and safest decision for your cat.

divider cat paws oct 2024

Vaccine Overview

You are free to use this image but we do require you to link back to Catster.com for credit

Vaccines are one of the most controversial topics when it comes to both humans and animals, and making the right decision can be a stressful and confusing process for pet owners.

It is essential to understand that no vaccine is 100% safe, and it’s also important to be aware and acknowledge that vaccines also save lives. Vaccines are preparations of microbes, like bacteria or viruses, that have been manipulated or inactivated so that they don’t cause a disease process. By administering these vaccines to the animal, it trains the immune system to protect against the agents targeted by the vaccine.

There are two classifications of cat vaccinations: core and non-core vaccinations. Core vaccinations are recommended for all cats to protect them from common and severe conditions.

They include:
  • Rabies: Rabies kills several mammals every year, and there is no cure. Rabies vaccinations are required in most states in America.
  • Calicivirus, Feline Viral Rhinotracheitis, and Panleukopenia (FVRCP): This combination vaccine, commonly known as the distemper shot, protects against viral infection rhinotracheitis, calicivirus, and panleukopenia.
  • Type I feline herpesvirus (FHV, FHV-1): This is the leading cause of upper respiratory infections.
  • Feline Leukemia Virus (Felv): This vaccine is considered a core vaccine for kittens and young adult cats under 1 year of age. Even if it protects against a viral infection spread by close contact, if your cat typically stays inside, you never know if it will jump out or escape one day.
cat getting a shot from a vet
Image Credit: Kachalkina Veronika, Shutterstock

Non-core vaccinations are recommended for outdoor cats.

They include:
  • Feline Immunodeficiency Virus (Felv):  Also known as cat’s AIDS, this attacks the cat’s immune system and is normally spread through bites.
  • Feline infectious peritonitis (FIP): Is caused by a coronavirus and normally spread through feces.
  • Chlamydophila felis: Is a bacteria that causes respiratory disease in cats. It is normally transmitted from cat to cat, especially in crowded conditions.
  • Bordetella: This vaccine is recommended to protect your cat from the bacteria Bordetella, which can cause upper respiratory infections that are highly contagious. Your vet may recommend this if your cat is around a lot of other animals.

divider cats oct 2024

What to Consider?

Before giving your pet a vaccine, you should consider your cat’s overall health and the risk factors it is exposed to, the prevalence of disease in your area, consequences of infection, previous vaccine reaction, vaccine efficacy, duration of immunity, and vaccine properties. As you see, even indoor cats need to be protected against certain viral agents. It’s best to consult your veterinarian about your cat’s vaccination schedule and keep them up to date.

If you need to speak with a vet but can't get to one, head over to PangoVet. It's an online service where you can talk to a vet online and get the advice you need for your pet — all at an affordable price!

PangoVet_Mention-in-Content for PangoVet2 save money

Benefits and Drawbacks of Vaccines

Vaccinating your cat can help protect it and other cats from serious diseases. It will also help protect people from diseases, such as rabies, that can be transmitted by cats.

Vaccinations can also have reactions that range from mild to severe. Every cat can react differently, but there are a few signs you can look out for.

  • Swelling: Lumps and swelling in specific areas are also common side effects. A firm bump usually develops at the injection site. It’s essential to keep an eye on it for signs of inflammation, growth, or infection. It typically passes within a week, but if it doesn’t, and it has grown or seems infected, you will need to contact your vet.
  • Lethargy and a mild fever: These signs should be mild and last only 1 or 2 days, but if it goes on longer than 2 days, you should consult your vet.
  • Cold-like signs: Some vaccines are administered through your cat’s nose or eyes, which can lead to cold-like signs, such as sneezing, coughing, and a runny nose, but it should pass within a day or two.

If your cat has a severe reaction from a vaccine, the signs will appear either straight away or up to 48 hours later. These signs include facial swelling, vomiting, diarrhea, and difficulty breathing.  Anaphylaxis is the most severe allergic reaction that pets can experience due to vaccinations, and it can be life threatening if not treated immediately.

Several studies have found a link between the FVRCP vaccine’s excessive use (hyperinoculation) and kidney inflammation. The FVRCP vaccine is made from feline kidney cells; when injected into your cat, the body recognizes them as foreign and produces antibodies.

Unfortunately, those antibodies do not distinguish between the injected kidney cells and the cat’s kidney tissue, which can result in an autoimmune attack on its kidneys. However, more research is needed to determine whether vaccines cause or contribute to feline kidney disease.

sick cat
Image Credit: sick cat, Flickr

Keeping Your Cat Safe

Vaccines can be a vital part of keeping your cat safe, and your cat is most likely to be safe from a severe vaccine reaction.

Cats are no different from humans regarding needles, so you will need to make their visit to the vet as comfortable as possible. Use a sturdy and comfortable carrier with their favorite toy or blanket so that they can recognize the smell. Cats are sensitive and can pick up on your energy, so it’s important to stay as calm as possible.

When you arrive home, provide a warm, safe space for your cat to lie down and make sure they have access to water and food. Keep checking up on your cat, ensuring they are comfortable, but also try not to disturb them too much.

Adjuvants are substances added to vaccines that cause inflammation at the injection site, alerting the immune system to the presence of the vaccine. This substance can sadly cause an aggressive tumor that can be fatal, known as sarcoma. It’s essential to ask your vet about the vaccines they are using and avoid vaccines with adjuvants.

If a cat requires two vaccines, they can be given at least 1 week apart. This allows time for the first vaccine’s inflammation to decrease before administering the second. Another valid reason for separating vaccines is that the immune system can only do so much at once.

divider cats oct 2024

Conclusion

There are many variables regarding vaccines, and your comfort level after research also plays a role in the decision. Core vaccinations for cats are highly recommended, especially rabies, since the disease can also be passed to humans, and there is no cure.

Cats that live indoors should also be protected since they could go roaming, escape, or be surrounded by other cats when visiting a grooming parlor or boarding facility. While all vaccines are not 100% safe, they also save lives, so weighing the pros and cons is vital to the decision-making process. At the end of the day, we all want to keep our pets safe, and it’s up to you as the parent to make the best-informed decision.


Featured Image credit: Yoshihide KIMUR, Shutterstock

How useful was this post?

Click on a star to rate (you can leave written feedback after clicking submit)

Help us improve Catster for pet parents!

Your feedback really matters.

What did you like about this post? Also how can we improve it?

Join the conversation

Leave a Reply

You’re very welcome to leave a comment or question. Please know that all comments must meet our community guidelines, and your email address will NOT be published. Let’s have a positive and constructive conversation.

Talk With A Vet Online

Peace of mind,
anywhere, anytime

Affordable vet advice

How to Tell if a Cat Is Choking: 6 Vet-Reviewed Signs & What to Do

If your cat is choking, you need to ask fast, but before you try to give your cat the Heimlich, you should know...

10 Best Cat Litter Mats of 2025 – Reviews & Top Picks

Looking for the perfect cat litter mat to keep your home clean and litter-free? Our comprehensive reviews and top picks will help you...

Do You Get Too Attached to the Feral Cats in Your Care?

The relationships we form with feral cats can be quite intriguing. How do we help them without getting too attached to them? Ferals...

Can Cats Eat Pesto? Vet-Approved Risks & Safe Alternatives

Pesto is a household staple used in various foods, such as salad dressing, pizza, and chicken—the possibilities are limitless! If you’re a cat...

More related

Rad Cat Raw Food Diet – Are They Still in Business? Facts, Recalls & FAQ

An increasing number of pet parents are turning to raw food as a diet for their fuzzy companions. However, dealing with raw food,...

Mythical Cats: Exploring 14 Cats from Ancient Mythology

There’s nothing more interesting than diving into myths and legends that have been told throughout history. For cat lovers, you will find that...

Is Disciplining a Cat Useful or Effective? Olga Says No!

Hi, I’m Christopher! Read my introduction to learn more about me and my silly Russian Blue cat, Olga. Cats fill our lives with...

How to Introduce a Third Cat to Your Home (11 Vet-Reviewed Tips)

If there’s one thing to know about cat lovers, it’s that they cannot get enough of their cat. You can find many cat...

Keep reading

What Shots Do Kittens Need? Vet-Reviewed Schedule, Facts & FAQ

Kittens need several vaccinations to protect them from infectious diseases. All kittens are susceptible to these diseases, no matter what their breed is. Therefore, these vaccinations are highly recommended and a part of most kitten’s early vet care. Let’s look...

vet giving kitten vaccine

Best Way to Feed a Cat: Times, Amounts & Frequencies Explained

Many cats are more than happy to make it known when they want to be fed, but they may not know when and how much they actually should be fed. Some of us like to eat too much, and cats...

man feeding his hungry cat at home

5 Best Cat Foods for Feral Cats in 2025 – Reviews & Top Picks

If you are used to feeding feral cats, you probably think of them as your own. After all, it takes a lot of responsibility and care to look after animals with nowhere to go and no reliable source of food....

feral calico cat

Can Cats Eat Margarine? Health Risks & Advice

Cats do the craziest things when we least expect it, and that’s part of why we love them so much. There’s rarely a day that passes where your cat doesn’t leave you in giggles! Their eating habits tend to mimic...

Can Cats Eat Margarine

DIY Cat Shampoo: 3 Homemade Recipes With Simple Ingredients

As a cat owner, you usually don’t need to worry about giving your cat a bath all that often. But sometimes it’s necessary—perhaps your cat isn’t able to groom themself, or they’ve gotten into something particularly nasty that they probably...

Girl washes cat in the bath

My Cat Ate Cheese: Vet Approved Advice on What to Do

Cats are curious creatures that love to explore their environment. They often stumble upon various human foods on their adventures, which will likely result in tasting them. However, certain foods could be toxic or dangerous to cats. One common human...

My Cat Ate Cheese

Why Do Cats Like Sitting on Laps? 5 Vet-Verified Reasons

Cats generally love to curl up and sit on laps, and it’s a favorite feline activity. If you have a lap cat at home, you may wonder why your buddy loves sitting on your lap so much. Cats sit on...

Domestic cat lying on owner's lap

Nature’s Variety Instinct Cat Food Review of 2025: Recalls, Pros & Cons

Review Summary Nature’s Variety is the brand behind Instinct cat foods, available as wet canned food, dry kibble, and toppers. Its inspiration is knowing that raw diets have the potential to provide your cat with many different health benefits. It’s...

Instinct Cat Food Review