Get

In Your Inbox

Catster is reader-supported. When you buy via links on our site, we may earn an affiliate commission at no cost to you. Learn more.

How to Make a Cat Feel Better After Vaccines: 3 Vet-Approved Tips

smiling female veterinarian petting a cat

Vaccines are vital for any cat’s long-term well-being and quality of life, but for a short period after receiving them, shots can cause several irritating side effects. Mild pain is typical, as is mild tiredness. Depending on your cat’s personality the stress of the vet visit could contribute to their signs. Though recovering from vaccines is usually quick and easy, some cats can use the extra help to recuperate as fast as possible over the ensuing 2 to 3 days.

Keeping your cat comfy isn’t complicated, and you’ll enjoy the peace of mind that they’re safe, healthy, and content. We’ll show you how to make your cat feel better after getting vaccinated quickly and easily with these three tips for post-shot care.

divider 1 paws

The 3 Tips to Make Your Cat Feel Better After Vaccines

1. Give Your Cat a Soft Bed in a Safe Area

If your cat is sore and tired after getting vaccinated, they’ll appreciate a cozy bed where they can rest. Provide a soft, warm sleeping area where your cat can easily access their litter box and food bowl.

It isn’t uncommon for cats to withdraw a little after getting shots, so you should consider their desire for privacy as you arrange their comfy space. Set it up in a quiet, out-of-the-way area in a bedroom or spare room with less traffic to help your cat feel secure.

cat lying on the cat bed on the couch
Image Credit: Iva Vagnerova, Shutterstock

2. Watch for Signs of Agitation and Give Your Cat Space

The vaccination process, from the trip to the vet to the soreness following the shots, can leave cats feeling edgy, which you may interpret as aggressiveness or distrust.

While this will generally fade after a day or two as your cat settles back into the routine, you should be aware of their body language and allow them to engage you rather than force interactions. Give your cat space if they want it, and offer gentle affection when they want to snuggle with you. You can also try calming pheromone sprays or supplements to help relax your cat.


3. Check on Your Cat Frequently

Although you’ll give your cat their necessary alone time to let them rest, relax, and recover, you should also keep tabs on them to ensure they’re comfortable and making steady progress. Check on your cat frequently for signs of discomfort or unwanted reactions to the shots. Keep the water and food bowls clean, filled, and accessible, but don’t worry if your cat isn’t overly hungry.

sleepy cat laying on the lap of owner
Image Credit: Aleneza Ozerova, Shutterstock

divider 1 paws

What Are the Most Common Side Effects of Vaccine Shots?

Adverse reactions to vaccines are uncommon, as one survey found they occurred in only 0.52% of cats within 30 days after vaccination. Cats around a year old are the most at risk of experiencing issues. Adverse reactions become more likely as cats receive more vaccines in one visit.

The most common adverse reactions cats experience after a vaccination include:

  • Lethargy
  • Loss of appetite
  • Fever
  • Inflammation at the injection site

Cats may also experience mild to severe allergic responses causing facial swelling, breathing difficulty, itchiness, vomiting, or collapse. Anaphylaxis typically occurs within 20–30 minutes after vaccination. Owners must seek immediate veterinary care if their cats show signs like these.

Innate responses cause many common adverse effects and are expected consequences of the vaccine stimulating the body’s immune system.

If you are concerned about your cat after they’ve received shots, you should contact a veterinarian.

If you need to speak with a vet but can't get to one, head over to PangoVet. It's an online service where you can talk to a vet online and get the advice you need for your pet — all at an affordable price!

PangoVet_Mention-in-Content for PangoVet2 save money

Feline Injection-Site Sarcoma

Feline injection-site sarcoma (FISS) is a rare occurrence and one of the most severe vaccine-associated adverse effects. The malignant tumors may appear anywhere from a few months to several years after cats receive an injection and, if left untreated, can be fatal as the cancer metastasizes to other organs in 10-28% of cases.

Swelling or lumps at the injection site may occur in vaccinated cats, usually disappearing within several days. Vets often advise clients to follow the 3-2-1 rule in assessing swelling after vaccinations. Masses need further investigation if they meet any of the following criteria:

  • They persist for longer than 3 months
  • They become larger than 2 centimeters in diameter
  • They grow in size a month after vaccination

Your cat may need a biopsy for a FISS diagnosis, potentially alongside imaging such as CT scans. Complete surgical removal of the mass is more likely when it is small, so timely investigations can save your cat’s life. Allowing the mass to grow and potentially spread worsens the prognosis. Following surgery, radiation or immunotherapy can improve your cat’s chances.

Cat sleeping like a pretzel
Image Credit: Corina P, Shutterstock

divider 1 paws

How Often Do Cats Need Vaccinations?

Cats generally receive vaccinations starting 6–8 weeks after birth. Vets then time additional vaccinations every 4 weeks until the cat reaches 16–20 weeks old. The core vaccines recommended for all cats include:

  • Feline panleukopenia virus, feline viral rhinotracheitis, and feline calicivirus vaccines combined into one (FPV/FHV-1/FCV)
  • Rabies

Healthy cats typically need vaccine boosters every 1-3 years, depending on the vaccine and the cat’s risk of infectious disease. Vets assess individual exposure risks to form vaccination plans and may recommend non-core vaccines, such as those for feline leukemia virus, Bordetella, and chlamydia, depending on the cat’s environment, health status, medical history, and lifestyle.

divider 1 paws

Conclusion

Vaccinations rarely cause any adverse effects in cats, and for those who feel a little tired or under the weather, the benefits still vastly outweigh the risks.

Monitor your pet for the few days after they get their shots, and don’t hesitate to follow up with the vet if they show abnormal swelling or other signs or reactions. Otherwise, keep your cat comfy; they will feel better faster and be ready for the next round of shots.


Featured Image Credit: Prostock studio, Shutterstock

Want content like this delivered to you?

Sign Up For Our Newsletter

News, insights, expert advice, and everything cat

* By submitting, you agree to our Terms & Conditions and Privacy & Cookies Policy.

How useful was this post?

Click on a star to rate (you can leave written feedback after clicking submit)

Help us improve Catster for pet parents!

Your feedback really matters.

What did you like about this post? Also how can we improve it?

Join the conversation

Leave a Reply

You’re very welcome to leave a comment or question. Please know that all comments must meet our community guidelines, and your email address will NOT be published. Let’s have a positive and constructive conversation.

Talk With A Vet Online

Peace of mind,
anywhere, anytime

Affordable vet advice

TrustedHousesitters Review 2025: Our Expert’s Opinion

Making travel plans can be a stressful experience, but cat owners face the added challenge of finding safe and trustworthy care for their...

Maine Coon Kittens for Sale in Pennsylvania: Breeders List 2025

Catster advocates for adopting before shopping, though we fully understand there are many reasons for seeking a breeder. So, we encourage it to...

10 Best Halloween Cat Toys of 2025 – Reviews & Top Picks

Halloween can be a fun time of year, but we often overlook our kitties. While cats may not understand the concept of a...

Do Cats Lick Themselves to Get Your Scent Off? 3 Surprising Theories

Have you ever noticed your cat licking themself after being around you or right after you pet them? That’s because cats lick themselves...

More related

Why Is My Cat Laying On Me All of a Sudden? 12 Vet-Reviewed Reasons

If you have a standoffish cat or one that simply doesn’t care much for snuggling, it can be special when your cat suddenly...

What Are Struvite Crystals in Cats? Our Vet Explains Causes & Treatments

If you notice any changes in your cat’s urination habits, this could be a sign of an issue with the urinary tract and...

Why Do Cats Slap and Swat? 9 Vet-Reviewed Reasons & Tips

Cats, elegant and beautiful as they are, have some pretty perplexing behaviors. On top of the list is slapping and swatting anything (and...

Is It True That All Cats Get Hairballs? Vet-Reviewed Facts & FAQ

Have you ever been woken out of a deep sleep by the sound of your cat dry heaving on the bedroom floor? More...

Keep reading

How Far Will a Female Cat in Heat Travel? Vet-Reviewed Info

If you have a female cat in heat, it’s common to worry that she might wander too far and lose her way home. Fortunately, female cats usually don’t travel that far in search of a mate. Keep reading while we...

Cat in heat lying down

Why Do Cats Lay in the Middle of the Floor? 7 Vet-Verified Reasons

Cat owners everywhere are familiar with the feline antics their furry roommates get up to, but it’s not always obvious why they do the peculiar things they do. For example, why do cats just lie in the middle of the...

cat lying on the floor and looking up

Ways to Play With a Cat Without Toys: 10 Vet-Approved Ideas

Keeping your cat entertained by playing is crucial for their health and well-being. Mental and physical stimulation keeps them in good physical shape and maintains an active lifestyle. It can also help prevent destructive or unwanted behaviors, such as attention...

Cute cat playing inside a paper bag

Why Is My Cat Hiding Suddenly: 12 Vet-Reviewed Reasons

Hiding is a behavior that pet owners may not see as often in dogs as in cats. However, it’s a safe bet that something is behind it that may either mean something benign or a more serious issue worth further...

A cat hiding under a couch

Why Does An Adult Cat Go Limp When You Grab Their Scruff? Vet-Verified Reasons & FAQ

When mother cats want to move their kittens, they gently bite the skin on their necks to lift them. The kittens almost always react the same way: They go completely limp. There’s even a scientific name for this inert, lifeless...

Owner grabbing a cat by the Scruff

11 Best Cat Foods for Urinary Tract Health in 2025: Reviews & Top Picks

Good urinary tract health is essential for your cat’s overall health. Many cats are prone to urinary tract infections. However, their owners may not even know it because cats are good at hiding their illnesses. Chronic urinary tract problems can...

Cat eating kibble from 2 raised cat bowls on the floor

Transitioning Your Cat to Raw Food: 5 Crucial Tips

There are arguments for and against a raw food diet for cats. Some say that it can be dangerous due to the prospect of contaminated meat and a lack of nutrients. Others say that it can be beneficial because it’s...

cat reaching dish with raw meat

How Long Do Outdoor Cats Live?? Average Lifespan & Info (Vet-Approved)

Under natural conditions, cats are potent predators that effectively stalk and capture prey in a variety of outdoor environments. However, cats have become domesticated in the last 10,000 years, and in modern times, the number of domesticated cats exponentially outnumbers...

Polydactyl orange tabby cat walking outdoor