A low number of red blood cells (also called erythrocytes), or anemia, can be found in cats in various pathologies. Anemia can make your cat feel weak and tired, have pale mucous membranes, breathe fast, and have no appetite. The number of red blood cells can be checked at a routine blood test, known as a complete blood count.

If your cat is anemic, your vet can increase the number of their red blood cells by several means, depending on the cause of their condition. In serious situations, when the anemia is severe, the vet may recommend a blood transfusion.

In this article, learn the role of red blood cells, the causes that can lead to the decrease of these cells, and how your vet can increase the number of erythrocytes.

How to Increase Red Blood Cells in Cats

If your cat is anemic, your vet will recommend several diagnostic procedures in order to get down to the bottom of the issue. They will start with blood testing and sometimes viral testing, chest and abdominal x-rays and scans, and additional urine, fecal, and blood tests, as required. Then your vet can recommend available and most appropriate options to increase the number of red cells in your cat.

This is not something you can do at home, particularly not without the vet’s advice and guidance. Treating anemia without knowing the cause is likely to be unsuccessful and harmful, and we cannot stress enough how important it is to consult with your vet.

Anemia in cats may be acute due to blood loss, autoimmune disease, or trauma, while chronic anemia is usually a consequence of an underlying slowly progressing disease, such as kidney disease, viral infections, liver disease, gastrointestinal disease and hemorrhage, cancer, or something else.

1. Administering Iron Supplements

Iron supplements should only be administered on the recommendation of a vet and if there is confirmed iron deficiency anemia, which is not very common in cats. Do not give iron supplements to your cat without talking to your vet, as they will need to perform blood tests first to establish blood iron levels and total iron binding capacity. Administering these supplements can be harmful and lead to liver damage if the dosage is too high.

If your vet has diagnosed your cat with a dietary deficiency or, more likely, a chronic illness that has led to iron deficiency anemia due to depletion of iron stores, your vet will recommend a particular iron supplement. Many of these supplements are not regulated, and their safety and efficacy may not have been established. It’s important to follow your vet’s recommendations when picking a suitable supplement.

Iron supplements should be used cautiously in pets with hemolytic anemia, hemosiderosis, or hemochromatosis and in pets with gastrointestinal ulcers. It should be used with caution in pregnant or lactating animals.

Too much iron in a cat’s body can damage the lining of the digestive tract and lead to liver damage, cirrhosis, and fibrosis.

2. Providing a Diet Rich in Iron

If your vet has confirmed an iron deficiency, they may also recommend you feed your cat foods rich in iron, such as:

Only change your cat’s diet after speaking with a vet.

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3. Doing a Blood Transfusion

This method of increasing your cat’s red cell count will always be recommended and performed in the veterinary office. Blood transfusion is necessary and can save your cat’s life if they have severe acute anemia. Your vet will blood type your cat and keep them in for observation to make sure they are not experiencing a transfusion reaction.

4. Erythropoiesis-stimulating Medications

There are several products that may help stimulate production of red blood cells. These medicines are considered when the patient is suffering with a chronic illness that leads to anemia, such as kidney disease, and they have clinical signs of anemia, meaning they are not coping well with their illness. There are recombinant human erythropoietin and darbepoetin, and both require cautious dosing and regular monitoring during treatment due to risk of severe adverse effects.

5. Novel Treatment

The U.S. Food and Drug Administration conditionally approved Varenzin-CA1 (molidustat oral suspension), the first drug for the control of nonregenerative anemia associated with chronic kidney disease in cats. Varenzin-CA1 works by helping to increase production of erythropoietin in the kidney, which in turn stimulates the bone marrow to produce more red blood cells. Speak to your vet about treatment options for your cat if they are suffering with anemia caused by chronic kidney disease.

What Do Red Blood Cells Do?

Red blood cells, or erythrocytes, are cells without nuclei that are found in the blood and are rich in hemoglobin. They are involved in cellular metabolism and ensure an optimal and constant blood pH.

The number of red cells is an important factor in the diagnosis of various pathologies. The most common medical conditions encountered in cats in which the number of red cells can be decreased are:

The increase or decrease in the number of red blood cells must be corroborated with other values from the complete blood count (e.g., hemoglobin, reticulocyte count, etc.) and with other tests, such as blood biochemistry, rapid tests, coagulation tests, etc.

What Causes Low Red Blood Cells in Cats?

The listed conditions can cause a decrease in the number of red cells through the following mechanisms:

In cats, the reference number for red blood cells is 6.9 to 10.1 x 106/µL. If the number of erythrocytes is below this reference range, it means your cat is suffering from anemia, which can be mild, moderate, or severe. Anemia can be regenerative and non-regenerative.

Regenerative Anemia

In regenerative anemia, the bone marrow still produces new erythrocytes.

Non-regenerative Anemia

In the case of non-regenerative anemia, the bone marrow can no longer produce sufficient amounts of new red blood cells.

How to Recognize Anemia in Cats: Clinical Signs

If your cat suffers from anemia, they will exhibit changes in their behavior due to a lower content of oxygen in the blood. Here are the clinical signs that you might notice if your cat has anemia:

Depending on what caused the anemia, your cat may also show other clinical signs. For example, if your cat has been poisoned with rat poison, bruises may appear on their body or gums, they may vomit blood and have bloody diarrhea or blood in urine, etc. If your pet has chronic kidney disease, they may experience extreme thirst and change their urination behavior.

If your cat displays any subtle clinical signs or changes their behavior, do not hesitate to contact the vet. The sooner your cat is evaluated, the better the chances of recovery.

How to Prevent Anemia in Cats

Anemia cannot always be prevented, but here is what you can do to reduce the risk of its occurrence:

Conclusion

Anemia can be a life-threatening problem for your cat. The clinical signs of anemia in cats can include tiredness, lethargy, lack of appetite, pale gums, and rapid breathing and heart rate. The number of red blood cells can decrease in various pathologies, the most common being trauma, tumors, internal bleeding, viral infections, and gastrointestinal, kidney, or other chronic diseases. A complete blood count will show the number of red cells, and the veterinarian will know if it is anemia or something else (corroborating with other test results).

To increase the number of red blood cells, the vet may recommend several ways to manage this condition based on the underlying cause. Never give your cat any iron or other supplements before speaking to your veterinarian, as it may cause more harm than good and will not treat the underlying issue.

• See also: Stem Cell Cat Therapy: Our Vet Explains How It Works, Side Effects & FAQ

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