Get

In Your Inbox

Catster is reader-supported. When you buy via links on our site, we may earn an affiliate commission at no cost to you. Learn more.

Buprenorphine for Cats: Usage, Dosage & Side Effects (Vet Answer)

young woman giving cat a tablet pill

Buprenorphine is a prescription-only drug that can be used for pain relief in cats. It belongs to a class of drugs called opioids, which provide very strong pain relief. In comparison to other opioid drugs, cats seem to respond well to buprenorphine and receive the benefits without experiencing many unwanted side effects.

In many countries, the use of buprenorphine is classed as “off-label.” This simply means that the medication is prescribed for use in a way that is not described on the medication label. Vets often prescribe medications this way and it is perfectly safe. There are some potential side effects of the use of buprenorphine in cats, but they are relatively rare.

Not all cats are good candidates for the use of buprenorphine. This does depend on their circumstances including any ongoing health issues. Your vet will be able to advise you on whether it can be safely used on your cat.

divider 3 paws

What Is Buprenorphine for Cats?

Buprenorphine is mainly used for pain relief in cats. It can be used to manage pain from surgical procedures such as neutering, fracture fixation, the repair of wounds, and dental procedures.

It is often used to manage chronic pain, for conditions such as arthritis. It can also be used for acute pain relief for trauma, injuries, or other painful situations where deemed necessary. In some cases, it is used to help cats that experience feline lower urinary tract disease (FLUTD). Buprenorphine can also be used as part of a pre-medication drug combination to give to cats before surgical procedures.

Buprenorphine is a DEA Schedule III controlled drug.1 This means there are strict rules around the prescribing and dispensing of the drug. It is illegal for owners to use, sell, or give the drug to any human or animal that it has not been prescribed for. In no circumstances should drugs prescribed for humans be given to cats or vice versa.

Buprenorphine should be stored at room temperature between 20°C and 25°C (68°F and 77°F). It should always be kept out of direct sunlight and excessive heat. It should be kept in a locked container as it is a controlled drug.

Always ensure only authorized personnel have access to Buprenorphine, and always keep out of the reach of children and animals.

woman giving cat a pill
Image Credit: New Africa, Shutterstock

How Is Buprenorphine Given?

There are a few different ways buprenorphine can be given to cats. Your vet will typically inject it when your cat is a patient in a veterinary hospital. The injection can be administered either subcutaneously, (under the skin) into the muscle or straight into the vein.

Buprenorphine is also available in the form of a transdermal patch, and can also be given orally in liquid form. It is not eaten as such, but rather sprayed onto the mucous membranes and allowed to soak in. It is usually absorbed after being squirted under your cat’s tongue or on the pouches of their cheek. This is thought to be the best way to manage chronic pain as the drug is readily absorbed by the tissues in the mouth.

The dose is always carefully calculated by your vet and will depend on your cat’s weight. It can be given with or without food.

Doses that are given orally by owners must be measured out and checked carefully as the drug is very potent and it is easy to overdose. There is no specific monitoring required for the use of buprenorphine in cats. Owners should be aware of the potential side effects and take their cats in for regular checkups while they are taking the medication.

What Happens if You Miss a Dose?

If you realize that you have missed a dose, give the missed dose as soon as you remember. After this, continue with the recommended time between each dose. If it is close to the next due dose, you will have to miss the dose and then continue as you have been instructed on the prescription.

Never give double doses or extra doses within the specified time frame.

vet-giving-pill-to-kitten
Image Credit: Andrew Rafalsky, Shutterstock

divider 3 paws

Potential Side Effects of Buprenorphine

Typically, the most common side effect seen is drowsiness/sedation.

Other common side effects include:

Usually, unwanted side effects will disappear if the dose is reduced, or the drug is stopped completely.

An overdose of buprenorphine is rare, but it can occur. Clinical signs include excessive sedation, slower movements and lack of coordination, drooling, and slower breathing rate. If you think you may have given your cat an overdose, contact your vet immediately.

If you need to speak with a vet but can't get to one, head over to PangoVet. It's an online service where you can talk to a vet online and get the advice you need for your pet — all at an affordable price!

PangoVet_Mention-in-Content for PangoVet2 save money

Other useful resources are:

divider cat paws 2 oct 2024

Frequently Asked Questions

How long does Buprenorphine last in cats?

The duration of action does depend on the route of administration. It usually has a lasting effect ranging from 6–12 hours.

Are there alternatives to Buprenorphine for cats?

There are many alternatives for the management of pain in cats. Commonly used drugs include non-steroidal anti-inflammatory drugs such as meloxicam, other opioids such as morphine, and local anesthetics such as lidocaine. Your vet will be able to discuss which type of drug is best suited to your cat’s individual needs.

How long can cats use Buprenorphine for?

Cats are usually prescribed buprenorphine for a few days at a time. Typically, this is after surgery or an injury where the cat requires a high level of pain relief. The long-term safety of the use of buprenorphine for over 5 consecutive days has not yet fully been investigated in cats.

divider cat paws 2 oct 2024

Conclusion

Buprenorphine is a valuable drug for the management of pain in cats. It provides strong analgesia for conditions such as post-surgical pain and acute injuries. It has a long-lasting effect on cats and can be given via multiple administration routes. This provides flexibility for individual cats in different scenarios.

It is a controlled drug, and it is very potent, so care must always be taken when administering doses and using it in general.

Related Reads: 


Featured Image Credit By: New Africa, Shutterstock

Want content like this delivered to you?

Sign Up For Our Newsletter

News, insights, expert advice, and everything cat

* By submitting, you agree to our Terms & Conditions and Privacy & Cookies Policy.

How useful was this post?

Click on a star to rate (you can leave written feedback after clicking submit)

Help us improve Catster for pet parents!

Your feedback really matters.

What did you like about this post? Also how can we improve it?

Join the conversation

Leave a Reply

You’re very welcome to leave a comment or question. Please know that all comments must meet our community guidelines, and your email address will NOT be published. Let’s have a positive and constructive conversation.

Talk With A Vet Online

Peace of mind,
anywhere, anytime

Affordable vet advice

Is Lysol Toxic To Cats? Ver Reviewed Concerns & Safety Tips

When you adopt a pet, you will probably find yourself cleaning more often. However, many of the cleaners that we use are filled...

Why Is My Cat’s Stomach Gurgling? 8 Vet-Reviewed Reasons

If your cat’s stomach is making odd noises, you may be wondering what’s going on and what causes it. Cat stomach gurgles are...

Itchy Pet Awareness Month – How and When Is It Celebrated?

August is Itchy Pet Awareness Month. Zoetis, a veterinary medication developer and manufacturer, created the event to raise awareness about pet skin allergies...

Orijen Cat Food Review of 2025: Recalls, Pros & Cons

Review Summary As you probably guessed, “Orijen” is a play on “origin”—meaning, the food harkens back to the origins of a cat’s diet....

More related

The 5 Stages of a Urinary Blockage in Cats: Vet-Verified Info & FAQ

Feline lower urinary tract disease (FLUTD) is a syndrome related to inflammation in the bladder and urethra. It’s one of the most frustrating...

Do Cats Throw Up When Stressed? Vet-Verified Facts & Considerations

It sometimes feels like cats and vomiting go hand in hand, although that’s certainly not something a healthy cat should be doing regularly....

Can Cats Eat Turkey? Vet-Reviewed Nutrition Facts & FAQ

Turkey is often touted as a fantastic low-fat protein source for people. It’s tasty and packed with nutrients, including magnesium, potassium, and tons...

How to Use Sisal Rope for Cat Trees: 3 Important Things to Know

Sisal rope is the best option for cat scratching posts out there. For this reason, it is often utilized on cat climbing structures...

Keep reading

10 Best Wet Cat Foods in the UK in 2025: Reviews & Top Picks

As cat lovers, we want what’s best for our kitties, and that involves feeding healthy cat food that provides all the necessary ingredients cats need to thrive. When it comes to wet cat food in the UK, you’ll see plenty...

orange cat eating wet food

Does Tea Tree Oil Kill Fleas on Cats? Effectiveness & Safety Reviewed by Our Vet

If your cat has a serious flea problem, you could become desperate enough to try anything to resolve the issue. Waking up with several new red bumps along your skin and watching your cat scratch uncomfortably is never pleasant. Tea...

tea tree essential oil

Why Does My Cat Attack Me & No One Else? 7 Vet-Reviewed Reasons & What to Do

There are several reasons why your cat may choose to attack you and no one else. Oftentimes, cats, especially kittens and young adults, play rough if they haven’t been adequately socialized and find human fingers and hands to be a...

kittens training

How to Choose Cat Food: 10 Vet-Approved Tips & Tricks

Cats and humans have shared a mutually beneficial relationship for roughly 12,000 years. People developed agriculture, which attracted pests, and felines happily acted as pest control. The cat’s role in human society and their subsequent adaptation and domestication provide vital...

tabby kitten eating kibble from the feeding bowl

Will Stress Cause a Cat To Lose Their Hair? Vet Approved Facts & FAQ

Several problems, conditions, and situations can cause a cat to lose its hair. One of those conditions is something we humans regularly face, stress. Yes, stress can cause your cat to lose its hair, a condition called psychogenic alopecia. If...

cat losing hair

When to Euthanize a Cat? Vet-Reviewed Factors & FAQ

Watching a beloved family pet get old can be hard. As cats age, they will grow weaker and skinnier. Their behavior might change. They might not be the same cat that you used to know when they were younger. In...

a sick siberian cat being carried by owner

Do Cats Really Play With Their Prey Before Killing Them? Vet-Approved Behavior Explanation

We easily forget that our cute, fluffy cats are natural-born killers. Perfectly evolved to chase, stalk, and hunt small animals to devour them, even our domestic cats can often bring home their prey. Cats are often thought to be malicious...

cat hunting mouse outdoor

Can Cats Eat Poppy Seeds? Vet-Reviewed Risks & Precautions

While cats can be finicky eaters, sometimes they surprise us and gobble up things that aren’t a typical part of their diet. For instance, they might snack on a piece of banana that’s been left behind on the counter. They...

Can Cats Eat Poppy Seeds