Get

In Your Inbox

Catster is reader-supported. When you buy via links on our site, we may earn an affiliate commission at no cost to you. Learn more.

What Vaccines Do Indoor Cats Need? (Vet Answer)

Veterinarian giving injection to cat

Vaccines are designed to protect against a variety of feline diseases, including rabies virus, feline leukemia virus, feline distemper (also called parvovirus), feline calicivirus, and feline herpes virus.

One of the best ways to keep a cat healthy is to ensure that they get the specific vaccines they need, which should be discussed on an annual basis with a vet. Vaccines can consist of core and non-core vaccines, depending on a cat’s lifestyle (i.e., indoor vs outdoor, how often they might board in a cattery, etc.), age, and other risk factors. Core vaccines are designed to protect against infectious diseases that are either life-threatening or commonly encountered by the majority of cats. Non-core vaccines are those which may not be needed, depending on a particular cat’s risk factors.

To find out which vaccines an indoor cat generally needs and the timing of these vaccines, read on!

divider 1 paws

How Do Vaccines Work?

You are free to use this image but we do require you to link back to Catster.com for credit

Some vaccines, called “killed” vaccines, contain inactive DNA or RNA from a pathogen, such as a virus or bacteria. Some vaccines, called “modified live” vaccines,  contain less pathogenic forms of the normal virus or bacteria. Other vaccines, called “vectored” or “recombinant” vaccines, contain only a small part of a virus or bacteria inserted into an organism, called a plasmid, that acts to amplify this portion of the virus or bacteria once an animal is vaccinated.

Modified live and killed vaccines are some of the original, more traditional vaccines. Vectored vaccines are a more recent scientific development. Each type of vaccine has possible pros and cons.

After receiving a vaccine, the body recognizes the foreign material contained in the vaccine and produces an immune response. This response takes about 7–14 days to reach a peak response. This has to do with why vaccines are timed 3–4 weeks apart—to allow for this response and then a settling of the immune system before challenging it again with another vaccine.

Some vaccines made to combat infectious diseases that cats don’t routinely encounter, such as rabies, are considered effective after a single dose. Conversely, vaccines made to fight viruses that cats do commonly encounter or that may have antibodies received from their mom generally require a minimum of two doses, sometimes more, depending on the cat’s age.

What Vaccines Does an Indoor-Only Cat Need?

vet giving kitten vaccine
Image By: Ilike, Shutterstock

To determine what vaccines an indoor cat requires, they first need to be separated into kittens and adults.

Kittens receive their first vaccines in what is called a “primary vaccine course”. This involves vaccines that generally start around 8 weeks of age and continue every 3–4 weeks until they are 16 weeks of age or older. After 16 weeks of age, most kittens then need their next vaccine one year later.

Ages for a typical kitten primary vaccine course:
  • 8 weeks
  • 12 weeks
  • 16 weeks

Primary vaccines in kittens include their core vaccines (e.g., parvovirus, herpesvirus, and calicivirus), and potentially feline leukemia and rabies—depending on where they live, and their lifestyle risk factors. Rabies vaccines cannot be given to kittens until they are at least 12 weeks old.

Adult indoor cats fall into two categories for which vaccines they might need. Adult cats that have never been vaccinated generally get primary vaccines (just as a kitten would), along with a single booster 3–4 weeks later. The reason for this booster is that a single vaccine for herpes, calicivirus, and panleukopenia may not be fully effective—therefore, a second vaccine provides a bit more protection. Rabies, on the other hand, produces good results after a single vaccine, making a single vaccine sufficient.

Adult cats that received their primary course as kittens generally receive boosters either annually or triennially, depending on the vaccine, how much time they spend outside or boarding with other cats, as well as their age.

What Are the Minimum Vaccines My Indoor Cat Needs?

cat getting a shot from a vet
Image Credit: Kachalkina Veronika, Shutterstock

Once they are an adult, an indoor-only cat that lives in an area without rabies may only need the following vaccines:

The above may be given every three years for some low-risk cats. However, it is always a discussion to have with a veterinarian to determine what vaccines and what vaccine schedule your cat needs.

If you need to speak with a vet but can't get to one, head over to PangoVet. It's an online service where you can talk to a vet online and get the advice you need for your pet — all at an affordable price!

PangoVet_Mention-in-Content for PangoVet2 save money

Are There Instances Where a Cat Vaccine Schedule Might Change?

There are certain instances in which a cat may be deemed not healthy enough to receive a vaccine. Alternatively, it might be too early for them to receive a vaccine. A veterinarian may choose to delay vaccination of a cat for the following reasons:

  • Weight loss
  • Not eating
  • Urinary tract infection
  • Upper respiratory infection
  • Vomiting
  • Diarrhea
  • Too soon from the last vaccine

divider 1 paws

Frequently Asked Questions

What are possible vaccine side effects?

Veterinarian at vet clinic giving injection to cat
Image Credit: Tom Wang, Shutterstock

Vaccines, as with any medication, can have potential side effects. One of the more well-known side effects, particularly in cats, is called vaccine-associated fibrosarcoma. Fibrosarcoma is a cancer that forms from the cells forming the connective tissue layer under the skin. There is strong evidence to suggest that a combination of genetics, certain vaccines, and vaccine adjuvants can lead to the formation of these cancers in cats.

Many of these vaccines are now made in a different manner, to not contain adjuvants, and most vaccines in cats are also now given in specific locations of the body—so that if one of these cancers occurs, the vaccine that may have played a role can be identified.

Some common side effects of vaccines in cats include lethargy, vomiting, and diarrhea. Cats rarely develop anaphylaxis, or life-threatening allergic reactions to vaccines, facial swelling, and hives, the same way many other species are prone to developing. If your cat does experience any reactions to a vaccine, report it to a vet, as the way your cat is vaccinated may need to be adjusted moving forward.

How are vaccines given?

Most vaccines for cats are injections given under the skin and are generally about 1 ml in volume. Other forms of vaccines include nasal drops and transdermal vaccines, but these are uncommonly encountered.

My cat is late for their vaccine. Does that change the schedule?

It depends. If your cat’s a day or two late, or even a week late, for their annual booster, it is generally not a problem. If your cat’s more than a week or two late for their primary course booster, they may need an additional booster vaccine.

Is my cat too old for vaccines?

Generally, veterinarians no longer consider cats “too old” for most things. Sometimes, senior cats need the immunity provided by vaccines far more than adult cats. Discuss what risk factors exist for your senior cat—such as time spent outside, boarding around other cats and dogs, and any medical conditions—with a veterinarian to determine which vaccines they recommend and how often.

divider 1 paws

Conclusion

Vaccination in indoor cats is important in preventing serious illness and keeping our furry friends healthy. Vaccines are not just something done once when they are kittens; they are part of a lifelong health plan for your cat.


Featured Image Credit: Africa Studio, Shutterstock

Want content like this delivered to you?

Sign Up For Our Newsletter

News, insights, expert advice, and everything cat

* By submitting, you agree to our Terms & Conditions and Privacy & Cookies Policy.

How useful was this post?

Click on a star to rate (you can leave written feedback after clicking submit)

Help us improve Catster for pet parents!

Your feedback really matters.

What did you like about this post? Also how can we improve it?

Join the conversation

2 Responses

  1. My cat is five years old and received her shots about three years ago before I got her.. The vet keeps texting me to get her in for more shots. She is an indoor cat and has no other animals living with her. She is fed a steady diet of Royal Cabin D food plus a treat of Churu.
    I am 90 years old, live alone and am disabled. I have no one who can help get her in to the vet.
    How much risk to her health if she doesn't get more shots? J

    1. Hi John Benzon, beyond protecting your cat’s health, some of our pets shots, for example rabies, are required by law. You would need to find out what vaccines your vet is recommending to understand their urgency and importance as well as the potential risks for your cat. If you need guidance from a vet from your home, you can try contacting www.pangovet.com. They can help you through the next steps. But chances are you will need to either get someone to take you cat to the clinic or find a vet that offers house calls.

Leave a Reply

You’re very welcome to leave a comment or question. Please know that all comments must meet our community guidelines, and your email address will NOT be published. Let’s have a positive and constructive conversation.

Talk With A Vet Online

Peace of mind,
anywhere, anytime

Affordable vet advice

Why Don’t My Cats Cuddle With Each Other? 10 Vet-Approved Reasons

There are few things cuter than the sight of two cats snuggling together. When they start grooming each other, your heart just melts....

Where Should Cats Sleep at Night? 7 Expert Tips & Advice

While cats are mostly nocturnal, many of our furry companions like to match our schedules to spend more time with us. If that...

KitNipBox Cat Subscription Box Review 2025: Pros, Cons & Verdict

What Is KitNipBox? KitNipBox is a subscription cat box service based in New York City, NY. It delivers toys and treats straight to...

How Many Hours Does a Cat Sleep? Vet-Reviewed Facts & FAQ

If it seems like your cat sleeps a lot, it’s probably because it’s true. Cats love nothing more than having a few cat...

More related

Why Is My Cat So Small? Our Vet Explains

Who doesn’t love a kitten? A kitty will never be as small and energetic as they are in those first months of life....

Why Do Cats Curl Their Paws? Vet-Verified Reasons, Facts & FAQ

Cats have many adorable habits, one of which is their tendency to curl their paws underneath them and sit in a “loaf” shape....

Can Two Male Cats Get Along? Interesting Facts & FAQ

Cats can be kept in pairs or groups in a multi-cat household. If you have one cat and are tempted to get another,...

10 Best Cat Litters in Canada in 2025 – Reviews & Top Picks

Finding the right cat litter for your cat, let alone yourself, is definitely one of the more important purchases that you make as...

Keep reading

What Are E-Collars for Cats? Vet-Reviewed Types, Pros, Cons & FAQ

You may not immediately recognize the term “e-collar,” but you’ve definitely heard of them. You might know the e-collar by its more affectionately referred to term: the Cone of Shame. E-collars, or Elizabethan collars, as they’re more officially known, is...

cat wearing an ecollar

Hypertension In Cats: Vet Reviewed Signs, Causes & Care

Cats are beloved family members that rely on their humans for love, companionship, and care. However, cats that receive love, high-quality food, and plenty of exercise sometimes have medical conditions, including high blood pressure or hypertension. Left untreated, hypertension can...

checking blood pressure of cat

Why Do Cats Chatter at Birds? 5 Possible Reasons & FAQ

Cats are vocally gifted and can produce up to 21 distinct vocalizations.1 Although cat owners are accustomed to their pets meowing, they may be baffled by their chattering. Chattering is a unique sound that cats make after seeing prey, such...

cat and bird

Is It Safe for Cats to Eat Moths? Vet-Reviewed Facts & FAQ

Cats are natural predators that enjoy a good hunt, whether to catch a mouse running by or to chase butterflies in the sun. Typically, if they can catch their prey, they also have the instinctual drive to eat it. Although...

Cat Peeing on Dog Bed? 4 Reasons Why & How to Stop It!

When you first realize that your cat has peed on your dog’s bed, your first thought may be anger, followed by confusion. Do they not like the dog? To make matters worse, cat urine is tough to remove. It’ll take...

cat sitting near wet spot on bed

10 Best Cat Litters for Allergies in 2025 – Reviews & Top Picks

Just like humans, our cats can suffer from allergies, and it’s no fun for them at all! If you notice your cat sneezing, wheezing, and generally looking a bit miserable, it’s important to try and figure out if they’re having...

ginger cat inside red grey enclosed litter box

Can Cats Eat Anchovies? Vet-Reviewed Facts & FAQ

Cats love meaty treats, and anchovies are no different. In fact, anchovies are a moderately healthy food that many cats love. They make a great natural alternative to commercially available cat treats and giving your cat a few anchovies along...

Can Cats Eat Anchovies

Foods for Cats With Kidney Disease: The Right Things to Look For (Vet-Reviewed)

Receiving the news that your beloved cat has kidney disease can be devastating. However, with proper care, medications, and food, the disease can be managed, and, depending on the stage of the disease, your cat may still have many years...

Hungry cat sitting in front of a emty food dish and looking up