Get

In Your Inbox

Catster is reader-supported. When you buy via links on our site, we may earn an affiliate commission at no cost to you. Learn more.

Buprenorphine for Cats: Usage, Dosage & Side Effects (Vet Answer)

young woman giving cat a tablet pill

Buprenorphine is a prescription-only drug that can be used for pain relief in cats. It belongs to a class of drugs called opioids, which provide very strong pain relief. In comparison to other opioid drugs, cats seem to respond well to buprenorphine and receive the benefits without experiencing many unwanted side effects.

In many countries, the use of buprenorphine is classed as “off-label.” This simply means that the medication is prescribed for use in a way that is not described on the medication label. Vets often prescribe medications this way and it is perfectly safe. There are some potential side effects of the use of buprenorphine in cats, but they are relatively rare.

Not all cats are good candidates for the use of buprenorphine. This does depend on their circumstances including any ongoing health issues. Your vet will be able to advise you on whether it can be safely used on your cat.

divider 3 paws

What Is Buprenorphine for Cats?

Buprenorphine is mainly used for pain relief in cats. It can be used to manage pain from surgical procedures such as neutering, fracture fixation, the repair of wounds, and dental procedures.

It is often used to manage chronic pain, for conditions such as arthritis. It can also be used for acute pain relief for trauma, injuries, or other painful situations where deemed necessary. In some cases, it is used to help cats that experience feline lower urinary tract disease (FLUTD). Buprenorphine can also be used as part of a pre-medication drug combination to give to cats before surgical procedures.

Buprenorphine is a DEA Schedule III controlled drug.1 This means there are strict rules around the prescribing and dispensing of the drug. It is illegal for owners to use, sell, or give the drug to any human or animal that it has not been prescribed for. In no circumstances should drugs prescribed for humans be given to cats or vice versa.

Buprenorphine should be stored at room temperature between 20°C and 25°C (68°F and 77°F). It should always be kept out of direct sunlight and excessive heat. It should be kept in a locked container as it is a controlled drug.

Always ensure only authorized personnel have access to Buprenorphine, and always keep out of the reach of children and animals.

woman giving cat a pill
Image Credit: New Africa, Shutterstock

How Is Buprenorphine Given?

There are a few different ways buprenorphine can be given to cats. Your vet will typically inject it when your cat is a patient in a veterinary hospital. The injection can be administered either subcutaneously, (under the skin) into the muscle or straight into the vein.

Buprenorphine is also available in the form of a transdermal patch, and can also be given orally in liquid form. It is not eaten as such, but rather sprayed onto the mucous membranes and allowed to soak in. It is usually absorbed after being squirted under your cat’s tongue or on the pouches of their cheek. This is thought to be the best way to manage chronic pain as the drug is readily absorbed by the tissues in the mouth.

The dose is always carefully calculated by your vet and will depend on your cat’s weight. It can be given with or without food.

Doses that are given orally by owners must be measured out and checked carefully as the drug is very potent and it is easy to overdose. There is no specific monitoring required for the use of buprenorphine in cats. Owners should be aware of the potential side effects and take their cats in for regular checkups while they are taking the medication.

What Happens if You Miss a Dose?

If you realize that you have missed a dose, give the missed dose as soon as you remember. After this, continue with the recommended time between each dose. If it is close to the next due dose, you will have to miss the dose and then continue as you have been instructed on the prescription.

Never give double doses or extra doses within the specified time frame.

vet-giving-pill-to-kitten
Image Credit: Andrew Rafalsky, Shutterstock

divider 3 paws

Potential Side Effects of Buprenorphine

Typically, the most common side effect seen is drowsiness/sedation.

Other common side effects include:

Usually, unwanted side effects will disappear if the dose is reduced, or the drug is stopped completely.

An overdose of buprenorphine is rare, but it can occur. Clinical signs include excessive sedation, slower movements and lack of coordination, drooling, and slower breathing rate. If you think you may have given your cat an overdose, contact your vet immediately.

If you need to speak with a vet but can't get to one, head over to PangoVet. It's an online service where you can talk to a vet online and get the advice you need for your pet — all at an affordable price!

PangoVet_Mention-in-Content for PangoVet2 save money

Other useful resources are:

divider cat paws 2 oct 2024

Frequently Asked Questions

How long does Buprenorphine last in cats?

The duration of action does depend on the route of administration. It usually has a lasting effect ranging from 6–12 hours.

Are there alternatives to Buprenorphine for cats?

There are many alternatives for the management of pain in cats. Commonly used drugs include non-steroidal anti-inflammatory drugs such as meloxicam, other opioids such as morphine, and local anesthetics such as lidocaine. Your vet will be able to discuss which type of drug is best suited to your cat’s individual needs.

How long can cats use Buprenorphine for?

Cats are usually prescribed buprenorphine for a few days at a time. Typically, this is after surgery or an injury where the cat requires a high level of pain relief. The long-term safety of the use of buprenorphine for over 5 consecutive days has not yet fully been investigated in cats.

divider cat paws 2 oct 2024

Conclusion

Buprenorphine is a valuable drug for the management of pain in cats. It provides strong analgesia for conditions such as post-surgical pain and acute injuries. It has a long-lasting effect on cats and can be given via multiple administration routes. This provides flexibility for individual cats in different scenarios.

It is a controlled drug, and it is very potent, so care must always be taken when administering doses and using it in general.

Related Reads: 


Featured Image Credit By: New Africa, Shutterstock

How useful was this post?

Click on a star to rate (you can leave written feedback after clicking submit)

Help us improve Catster for pet parents!

Your feedback really matters.

What did you like about this post? Also how can we improve it?

Join the conversation

Leave a Reply

You’re very welcome to leave a comment or question. Please know that all comments must meet our community guidelines, and your email address will NOT be published. Let’s have a positive and constructive conversation.

Talk With A Vet Online

Peace of mind,
anywhere, anytime

Affordable vet advice

Pancreatic Cancer in Cats: Our Vet Explains the Causes, Signs & Care

Pancreatic cancer is a diagnosis that no cat owner ever wants to hear about their cat. Because the pancreas has many roles within...

Whipworms in Cats: Causes, Signs & Care Tips

Roundworms, hookworms, tapeworms, and heartworms are all common internal parasites that can cause many health problems for cats.1 Their presence in your cat’s...

Can Cats Drink Soda? Vet Approved Nutrition & Safety

Are you a soda lover who can’t go a day without a big, tall glass of your favorite fizzy drink? If you’re also...

9 Best Cat Dewormers in 2025 – Reviews & Top Picks

You’ve seen worms in your cat’s stool. Parasites come in all shapes and sizes. Some are microscopic but wreak havoc on our cat’s...

More related

Can Cats Drink Oat Milk? Vet-Reviewed Facts & Safety Guide

While we try to lead more active lives and make smarter food choices, it’s sometimes easy to forget that the same considerations don’t...

9 Amazing Facts About Morris the Cat, the 9Lives Mascot

If you are familiar with 9Lives cat food, you know that there is always a cheerful orange tabby licking his chops for this...

Pet Expo (World of Dogs and Cats): Visiting Africa’s Biggest Pet Event

In 2022, the South African pet expo, previously known as WODAC, The World of Dogs and Cats, returned after two desolate years due...

Can Cats Eat Poppy Seeds? Vet-Reviewed Risks & Precautions

While cats can be finicky eaters, sometimes they surprise us and gobble up things that aren’t a typical part of their diet. For...

Keep reading

How to Stop a Cat From Moving Her Kittens: 5 Vet-Approved Tips to Try

Knowing that your cat is having a litter of cute kittens can be exciting, but after they’re born, there’s so much to keep an eye on as a cat owner. If you’ve noticed your cat is moving her kittens, you...

Mother cat running with newborn kitten in her mouth

Are Cat DNA Tests Accurate? How They Work & More (Vet Approved Guide)

Cats are an integral part of our lives. If we don’t own one ourselves, we might know somebody who does. We see cats on television shows and movies, and we even think of cats during Halloween and when certain superstitions...

cat blood test

How to Keep Cats Healthy: 10 Vet-Approved Tips to Boost Your Cat’s Mental & Physical Health

Cats are family members, and it makes sense for pet parents to do everything possible to ensure their companions get whatever they need to be happy and healthy. Creating cat-friendly environments by providing pets with activities and entertainment can go...

white cat with the owner

At What Age Do Cats Start Getting Arthritis? Vet Reviewed Early Signs & Recommendations

Being a cat owner includes dealing with various health conditions, particularly as they age. One common condition in senior pets is arthritis, which is often regarded as just a sign that a cat is naturally starting to slow down. Technically,...

Side view of lazy and old tabby cat stay on a bed at home

7 Best Glucosamine for Cats of 2025 – Reviews & Top Picks

Glucosamine can relieve joint problems in humans, and it can probably do the same thing for your cat. Whether your cat has arthritis or sore joints in old age, this supplement may put some pep back in your cat’s step....

LaPerm tri-colored cat

Why Is My Cat Licking the Floor? 6 Vet-Verified Reasons

Cats sometimes do the weirdest things, and licking the floor is just one way that cats confound their human servants. The good news is that this behavior is relatively normal, at least by cat standards, and has some benign causes....

cat lick the floor

Cat Does Not Purr: 4 Vet-Reviewed Reasons

It is not fully understood why cats purr or how they do it, but you can generally expect your beloved feline family member to purr when they are feeling content. Purring is typical of cats when they are being petted...

Tabby green eyed cat being pet

Can Cats Eat Sage? Vet-Reviewed Nutritional Facts & FAQ

If you have a cat and like plants, you know how hard it is to keep your furry friend away from them. We try our hardest to shoo them away, but our cats always seem one step ahead of us....

Can Cats Eat Sage