Get

In Your Inbox

Catster is reader-supported. When you buy via links on our site, we may earn an affiliate commission at no cost to you. Learn more.

Is Advantage 2 Safe for Cats? Medication, Dosage & Usage

Share

Catster_Is Advantage 2 Safe for Cats

Fleas are pesky pests. They live on our dogs and cats and can cause various problems: intense itching, tapeworms, and anemia, to name a few issues. There are many products on the market, so you might be wondering which to pick. Is Advantage 2 safe for your cat?

divider 1 paws

What Is Advantage 2?

Advantage 2 is a topical flea-prevention product for cats. Do not confuse it with Advantix, which is just for dogs and can be deadly for cats.

Elanco produces Advantage 2, which uses imidacloprid and pyriproxyfen to kill all flea life stages. According to the company, it’s effective for preventing and treating flea infestations. The medication comes in individual tubes and should be stored in a cool, dry place.

close up fleas on cat
Image By: KanphotoSS, Shutterstock

How Is Advantage 2 Given to Cats?

Advantage 2 comes in single-use tunes. You’ll apply it directly to your cat’s skin. Because you should not get it into your cat’s eyes or allow your cat to lick or ingest it, you should apply it at the base of your cat’s neck.

Your cat should be dry when you apply the product, as it’s not waterproof until 24 hours after application. Part the hair at the neck base and squeeze the tube after you’ve opened it.

You can purchase Advantage 2 in packs of 2, 4, or 6 tubes. It should not be used in cats under eight weeks of age. The sizes for cats are as follows:

  • Kitten: 2 to 5 pounds
  • Small cat: 5 to 9 pounds
  • Large cat: over 9 pounds

Advantage 2 should only be applied once every 30 days.

What Happens if You Miss a Dose of Advantage 2?

If you miss your cat’s dose of Advantage 2, apply it as soon as possible. Don’t double-up doses; wait 30 days before applying the next dose.

If you miss a dose, your cat won’t be protected against fleas, and it’ll take 12 hours after the application to fight off fleas. That means your cat will be at risk of itching, leading to hair loss, skin rashes, and other issues like a bacterial infection caused by Mycoplasma haemofelis.

Beige or cream coloured older cat resting on bed and scratching his ear
Image Credit By: Lubo Ivanko, Shutterstock

Potential Side Effects of Advantage 2

Advantage 2 tends to be well-tolerated in cats when used appropriately, such as applying the correct size to your cat. That’s not to say it’s without side effects. Advantage 2, like all topical flea prevention products, can cause skin irritation. Some cats develop hair loss at the site of application, and your cat might develop redness, itching, or rubbing at the application site.

Gastrointestinal signs are also possible, such as:
  • Vomiting
  • Diarrhea
  • Excessive salivation

You should not use Advantage 2 in a cat younger than eight weeks or weighing less than 2 pounds.

It’s important to know that Advantage 2, as with most pesticides, can be hazardous to humans. Neither you nor your cat should ingest the product, so wash your hands thoroughly after applying it to your cat. It can cause eye irritation, so the manufacturer recommends flushing the eye gently with water for 15 to 20 minutes and contacting a doctor or poison control.

Important Note

Advantix is a product made by the same company but labeled just for dogs. This product is highly toxic to cats and should never be used on felines. Permethrin, which is a pyrethroid compound, is safe for dogs. Cats lack the ability to metabolize the compound, so it becomes toxic very quickly. Some potential signs of permethrin toxic exposure include:

  • Tremors or shaking
  • Seizures
  • Ear twitches
  • Hypersalivation (drooling, sometimes excessively)
  • Agitation
  • Vomiting
  • Death

sick cat vomiting the food on a white background
Image Credit By: Tom Wang, Shutterstock

divider 1 paws

Frequently Asked Questions (FAQ)

Should my cat be treated for fleas?

Cats should be on flea prevention every month, even if they are strictly indoor cats. That’s a recommendation from the Companion Animal Parasite Council, as well as most veterinarians.

Even if your cat is an indoor-only cat, fleas can hitch a ride on your clothes and enter your house, wreaking havoc and transmitting various illnesses.

Fleas aren’t just dangerous to your cat. Did you know they can carry the bacteria responsible for the Black Plague, Yersinia pestis? Even today, some places have occurrences of the plague.

How long does it take to get rid of fleas?

Products like Advantage 2 may kill fleas within 12 hours, but that’s not going to get rid of all the fleas. It may take several months to get rid of all the fleas in your cat’s environment due to the flea life cycle. Fleas lay eggs that fall off your cat and into the environment. These eggs may take several weeks to hatch, just in time for your cat’s flea prevention to wear off in many cases. That’s one of the reasons monthly flea prevention is so important.

Why does my cat keep getting fleas even after treatment?

Because fleas lay eggs that end up in our cat’s environment, you might kill the fleas on your cat but have more hop on as they hatch. Your cat could also be exposed to fleas from infected animals or going outside, perpetuating the cycle.

divider 1 paws

Conclusion

Fleas can cause many issues for your cat and can be quite frustrating for you. Elanco’s Advantage 2 is generally well-tolerated by cats as a topical flea prevention.


Featured Image Credit: goodluz, Shutterstock

Want content like this delivered to you?

Sign Up For Our Newsletter

News, insights, expert advice, and everything cat

* By submitting, you agree to our Terms & Conditions and Privacy & Cookies Policy.




How useful was this post?

Click on a star to rate (you can leave written feedback after clicking submit)

Help us improve Catster for pet parents!

Your feedback really matters.

What did you like about this post? Also how can we improve it?

Join the conversation

4 Responses

  1. I want to apply Advantage to my 2 kittens, but they lick each other. What is your advice for this? Thank you.

    1. Hi Greg, yes, there is the risk of them ingesting the medication while allogrooming. for 4-8 hours until it's dry. For extra safety, apply the product at bedtime. Keep them separated overnight, allowing them to snooze in individual areas. By morning, it will be safe for them to be together. Remember, they should be at least 8 weeks old and weigh 2 pounds or more for this medication to be safe for them.

  2. I have a cat that was not be fleeing will for more than two weeks. I want to take him to a vet. but I have no job right now. so I don't have the money to take him there. I have been using average 2 on him 5 years old. he now 15 years old. He has not had any Serious illness or Side effects throughout all these years. But now I am concerned. I'm not sure if these are the side effects of the flea dropped or a virus. Or maybe even both. Let's have a wet mark on his face where he's been scratching it lot. It's been sneezing ,running nose and eyes, When he sleeps he seems to Shake A little Like he's cold or in pain. He was heading but it's soon to die down.He's still having some trouble breathing. I want to take him to a vet but at this time I can't. but I also don't want to see my baby boy Suffering. I don't know what to do. I need help with good advice take care him. I had this cat Since the day he was born.

    1. Hi Carrie, sorry to hear about your cat, by your description the cat is sick and needs to see a vet which you mention you already know. Here are some ideas of resources and alternatives that we hope help you to help him:
      https://www.catster.com/cat-health-care/cheap-vets-for-cats/
      https://www.catster.com/lifestyle/organizations-charities-that-will-help-pay-vet-bills/
      https://www.catster.com/felines-weekly/somebody-to-lean-on-financial-resources-for-cat-owners/
      https://www.catster.com/lifestyle/ways-kids-can-raise-money-to-help-cats/
      Hopefully, this inspires you to find a way!

Leave a Reply

You’re very welcome to leave a comment or question. Please know that all comments must meet our community guidelines, and your email address will NOT be published. Let’s have a positive and constructive conversation.


Talk With A Vet Online

Peace of mind,
anywhere, anytime

Affordable vet advice

Ask Dr. Paola – Help! My Momma Cat Is Very Thin! (May 18, 2026)

Welcome to our “Ask Dr. Paola” series, where every Monday we bring expert advice straight from Dr. Paola Cuevas (MVZ) to help our...

The Cat Biting Mistakes Most Owners Make (And What Works Instead)

Cat bites sent more than 400,000 people to emergency rooms in the US each year.1 Not scratches. Bites. And the reason they’re so...

Do Cats Cause Schizophrenia? Scientists Find a Link – Here’s What It Means

Being a fierce advocate (and occasional recipient of) mental health support and awareness, the term ‘crazy’ is not one I like to fling...

One in 100 Cats Gets Diabetes – Here’s How to Catch It Early

One in every 100 cats develops diabetes.1 That’s not a rare, unlucky condition reserved for cats with obvious health problems. It’s common enough...

More related

Are Oriental Shorthair Cats Friendly? Vet-Verified Facts & Info

Cats have a reputation for being extra independent, and sometimes even loners—but this is not always true. There are certain cat breeds out...

Welcome to Coastal Cats & Critters

As much as we all love cats, we also know that in many parts of the country (and the world), the problem of...

10 Best Dry Cat Foods in Canada in 2026 – Reviews & Top Picks

If you have a new cat and are looking for the best dry food or you need to switch your current cat’s food,...

How to Take Care of Your Cat’s Teeth: 8 Vet-Verified Tips

Dental problems are pretty common in cats. When plaque sits on their teeth, it hardens and develops into tartar. Tartar around the gum...

Keep reading

6 Great Activities for Cats at the Beach & Vet-Reviewed Tips (With Pictures)

If you’re planning on taking a vacation or day trip to the beach, the idea of leaving your cat behind is difficult. While dogs are considered man’s best friend, that doesn’t mean our kitty cats aren’t as important. In fact,...

cat walking on the beach

Why Do Some Cats Like Earwax? Vet-Verified Reasons for this Behavior

If you’ve noticed that your cats seem to have an affinity for ears and earwax, you’re not alone. Many cat owners first notice it when watching their cats groom each other. Often, cats seem to spend more time licking and...

Cat licking woman's ear

What’s the Price of Spaying or Neutering a Cat in the UK (2026 Costs)

Getting your cat spayed (female) or neutered (male) is a common and important consideration when you’re a new cat parent. The price of spaying and neutering varies on your cat’s sex—the procedure is more expensive for female cats—and your location....

two cats lying on a pillow

Cat Fighting Sounds: With Videos & Body Signals (Vet-Verified)

When cats play, it can seem like they’re fighting, but when they’re actually fighting, it can lead to big problems. So, how can you tell the difference, and what does real fighting sound and look like? It’s a lot to...

white-and-grey-shorthaired-cat-angry-hissing-attacking

Why Is My Cat in Heat So Much? Vet Approved Facts & FAQ

If this is your first time living with a queen, or a non-spayed cat, it might surprise you how often they go into heat. How much is normal, and when should you worry? We break down everything for you here....

cat in heat

How Much Does It Cost to Microchip a Cat? (2026 Update)

Few things in this world can make you feel as scared and helpless as realizing that your cat has gotten lost. Sadly, many cats that go missing are never found, and they either end up dying on the streets or...

microchipping cat

How to Tell the Difference Between a Cat Hairball & Cough: Vet-Reviewed Facts

Seasoned cat owners could hear a cat retching up a hairball from a mile away, but the sound might sound like a cough to an inexperienced owner. However, these two things are different, and it’s essential to tell the difference...

cat cough

How Long Do Ragdoll Cats Live? Vet-Verified Average Lifespan Data & Facts

Ragdoll cats get their name due to their unique behavior. They go limp when you pick one up, just like a ragdoll. They have been bred to be this laid back and are adorable. If you are considering adopting one...

Ragdoll Cat standing on the outside

Love Cats? So Do We! Join the Catster Community

Stay informed with expert pet care insights delivered straight to your inbox! Discover professional guidance on animal behavior, feeding tips, trusted product picks, and much more.




Sign up for the Catster Email Newsletter

Stay informed with expert pet care insights delivered straight to your inbox! Discover professional guidance on animal behavior, feeding tips, trusted product picks, and much more.