Get

In Your Inbox

Catster is reader-supported. When you buy via links on our site, we may earn an affiliate commission at no cost to you. Learn more.

Shots For Unvaccinated Cats & Older Kittens: 2026 Guide (Vet Answer)

Share

vet holding cat for vaccination

Cats require vaccinations to help protect them from common infectious diseases. Determining which vaccinations your cat may need can be stressful. In this article, we will discuss vaccinations available to our feline companions and recommended vaccine protocols. The American Animal Hospital Association1 and American Association of Feline Practitioners have developed guidelines often followed in the United States.2 It is important to note that vaccination requirements may vary based on your country, disease prevalence, and your pet’s lifestyle so always contact a veterinarian for their specific recommendations.

divider cat paws 2 oct 2024

The 5 Common Shots for Unvaccinated Cats and Older Kittens

1. Rabies

The rabies vaccination is required by law in many states and is considered a core vaccination. Kittens typically receive this vaccination between 12–16 weeks of age, but the age of vaccination is dependent on state laws and manufacturer guidelines.

After the initial vaccination is administered to a kitten or a cat with an unknown vaccine history, another rabies shot should be administered 1 year later. After this next vaccination, the rabies will need to be given every 1–3 years, depending on local law and the type of vaccination administered. Wildlife can serve as a potential reservoir for this virus, and once contracted, the disease is fatal.

cat-having-a-vaccine
Image Credit: Africa Studio, Shutterstock

2. FVRCP (Feline Distemper, FRCP, FVRCPP)

This combination of vaccinations helps protect cats against several different viral respiratory and gastrointestinal pathogens and is considered a core vaccination. The vaccination offers protection against feline viral rhinotracheitis (herpes), calicivirus, and panleukopenia (parvovirus). It is initially given in a series to kittens.

The vaccination can be given starting at 6 weeks and is then boosted every 3–4 weeks until the kitten is over 16 weeks of age. In adult cats without a history of vaccination, the vaccination is administered in a two-part series given close to 3 weeks apart. After the completion of the initial series, a kitten can receive an additional vaccine at 6 months, or at 1 year of age. Further vaccinations are administered every 1–3 years, depending on the vaccine type.


3. Feline Leukemia

Feline leukemia is a highly contagious virus that can cause immune suppression and cancer in affected cats. This vaccine is considered a core vaccine in kittens but is considered a non-core vaccine in adult cats, depending on their lifestyle.

This virus is most common in outdoor cats that have close interactions with other cats. It is also administered in a two-part series and then boosted 1 year later. This can be given to cats as young as 8 weeks of age. For cats that are going to have access to the outdoors or live in an environment where there is the risk of exposure to the virus, the vaccination can be continued. The frequency of revaccination will depend on the risk of exposure and the type of vaccine administered.

cat vaccination
Image Credit: YULIYA Shustik, Shutterstock

4. Feline Chlamydophila Disease

A vaccination against the bacterial agent Chlamydophila felis is available for cats with a high likelihood of illness. This bacterial pathogen can cause conjunctivitis and rhinitis, typically in young cats. The vaccination can be administered to kittens or adults without a vaccination history and should be administered according to the product label. This is considered a non-core vaccination and is only used in environments in which infection with chlamydia has been confirmed.


5. Bordetella

An uncommon, non-core vaccination available to cats is the Bordetella vaccination. Bordetella is an upper respiratory pathogen that can be spread amongst cats. The vaccination doesn’t offer complete protection but may be beneficial in environments where Bordetella has been confirmed. This attenuated live vaccination is given intranasally and should be administered according to the product label.

cat vaccination
Image Credit: YULIYA Shustik, Shutterstock

divider cat paws 2 oct 2024

Side Effects of Vaccinations

Following vaccination, cats may experience soreness, fever, and lethargy. On occasion, localized swelling may be noted. It is encouraged that reactions that occur following vaccination administration be reported to a veterinarian. In some situations, more serious hypersensitivity reactions may occur including anaphylaxis.

Injection site sarcomas can occur because of inflammation following injection. Fortunately, this is not a common occurrence since non-adjuvanted vaccinations have become more readily utilized. Sarcoma formation is still a possibility, and as a result, most veterinarians will administer vaccinations in a location that can allow for surgical removal if a sarcoma were to develop.

If you are concerned or have questions about your cat’s health, you can also speak to a vet from the comfort of your own home to help make a plan. They can determine when an in-clinic vet visit should be made.

If you have a question about your cat's health or behavior, why not Ask a Vet for Free with Catster. Our veterinary team answers reader questions and provides trusted advice to help you better understand your cat.

askavet on catster

Important Notes

It is critical to note that there are several different ways a vaccine is structured. For example, cat vaccines can be inactivated, recombinant, or attenuated live. Additionally, the routes of administration can also vary. As a result, vaccination protocols may differ depending on the product used. It is important to speak directly with a veterinarian regarding the vaccinations that they carry and their recommended dosing protocols.

divider cat paws 2 oct 2024

Conclusion

Vaccinations are at the core of preventative care. A veterinarian will be able to help guide you as to which vaccinations your cat should receive. This will be determined by the age of your cat and your cat’s lifestyle. It is imperative to note that no vaccination can offer 100% protection against illness; however, vaccinations can significantly reduce signs of illness.


Featured Image Credit: bmf.foto.de, Shutterstock

Want content like this delivered to you?

Sign Up For Our Newsletter

News, insights, expert advice, and everything cat

* By submitting, you agree to our Terms & Conditions and Privacy & Cookies Policy.




How useful was this post?

Click on a star to rate (you can leave written feedback after clicking submit)

Help us improve Catster for pet parents!

Your feedback really matters.

What did you like about this post? Also how can we improve it?

Join the conversation

Leave a Reply

You’re very welcome to leave a comment or question. Please know that all comments must meet our community guidelines, and your email address will NOT be published. Let’s have a positive and constructive conversation.


Catster's Digital Magazine is Back!

Vet-approved health & behavior advice

Real cat stories & community features

Ask Dr. Paola – My Cat Loves Eating Grass, But It Makes Her Vomit! (June 29, 2026)

Welcome to our “Ask Dr. Paola” series, where every Monday we bring expert advice straight from Dr. Paola Cuevas (MVZ) to help our...

Learning to Speak Cat with Anthony Smith

Many cat lovers know me through Learn to Speak Cat and Cattitude – Doggonit, cartoons that explore the often mysterious, occasionally mischievous, and...

Weird Cat Behaviors That Actually Make Perfect Sense

We have been sharing our lives with cats for thousands of years, yet we still find ourselves genuinely stumped by what they get...

The Dream of Talking to Cats Just Got Closer to Becoming a Reality

If you’ve ever wished your cat could simply tell you what they wanted, you’re not alone. From the meow that wakes you before...

More related

How Much Does It Cost to Spay or Neuter a Cat? 2026 Update (Vet-Verified)

Spaying and neutering are both common medical procedures recommended by veterinarians, breeders, and shelters. Spaying or neutering your cat removes the possibility of...

Cat Coat Genetics: Vet-Approved Facts & FAQ

Have you ever wondered how your cat ended up with the coat color that they did? Maybe you know that your cat had...

What Is a Feral Cat Colony? Important Facts, How to Help & More

The U.S. has over 60 million unowned cats roaming its streets and alleyways1. Feral cats are undomesticated cats that live in groups or...

Birman Cat vs Himalayan Cat: Notable Differences (With Pictures)

The Birman cat and the Himalayan cat are both beautiful breeds that, at first glance, look quite similar. Both of these cats have...

Keep reading

Is My Cat’s Jaw Broken? Vet-Reviewed Signs to Be Aware

Cats instinctively hide their pain, so it can be difficult to tell if something is amiss. If your cat is in pain, you will want to look out for subtle signs. These can include changes in behavior, routines, or posture....

Red cat dropping his jaw surprisingly

10 Best Fish Oil Supplements for Cats in 2026 – Reviews & Top Picks

Finding the right fish oil supplement can be a challenge for cat owners. The benefits of supplementing with fish oils are extraordinary and more and more owners are introducing this supplement into their feeding regime. It is always best to...

hand giving ginger cat some supplement using dropper

7 Most Annoying Sounds Cats Make: Possible Causes & Prevention Tips

Cats are adorable pets and can be some of the best companions and roommates. They look cute and can make cute sounds. In fact, some studies show that a cat’s purring may have therapeutic effects 1. However, there’s no denying...

Ginger tabby young cat sitting on a wooden floor looks up

Does Dawn Kill Fleas on Cats? Vet-Reviewed Effectiveness Explained

Dawn is a dish soap that has several uses beyond washing dishes. One of the claims is that it can kill fleas on cats as a surfactant, but it’s not the most effective way of getting rid of them. This...

dishwashing detergent dispenser on a womans hand

Do Cats Get Jealous of Dogs? Feline Emotions Explained (Vet-Reviewed)

Jealousy is a complex emotion that humans experience when they have feelings of insecurity or fear. While we don’t typically think of our cats as having similar feelings as we do, they appear to be capable of more than we...

Golden Retriever and British Shorthair accompany their owner

Is Your Cat Constipated? 12 Simple Remedies Vets Recommend Trying at Home

Few things worry cat parents more than when their kitty can’t go. Constipation is one of the most common digestive issues cats face — and one of the most uncomfortable. While some cases are mild and manageable at home, others...

cat outside the litter box

How to Tell if a Cat Is Scared (4 Vet-Reviewed Signs to Look For)

One of the hardest parts of being owned by a cat is not always knowing exactly how they’re feeling. As typically stoic animals, it can be difficult to tell if your cat is in discomfort or feeling vulnerable in some...

cat hiding

How to Cool Down a Cat: 9 Vet-Approved Tips

When the hot weather rolls around, it is imperative to know how to look after your cat. All felines, just like humans, can be at risk of overheating when it’s hot and humid, with the potential of causing heatstroke. Although...

blue-tabby-maine-coon-cat-playing-water

Love Cats? So Do We! Join the Catster Community

Stay informed with expert pet care insights delivered straight to your inbox! Discover professional guidance on animal behavior, feeding tips, trusted product picks, and much more.




Sign up for the Catster Email Newsletter

Stay informed with expert pet care insights delivered straight to your inbox! Discover professional guidance on animal behavior, feeding tips, trusted product picks, and much more.