Get

In Your Inbox

Catster is reader-supported. When you buy via links on our site, we may earn an affiliate commission at no cost to you. Learn more.

Pyometra in Cats: Our Vet Explains the Signs, Causes, Treatments & FAQ

Share

a siamese cat getting examined by a vet at the clinic

Pyometra in cats is a serious infection where your cat’s uterus fills with pus. Your cat can become very ill, and it can even be fatal.

It is thought to be caused by hormonal changes affecting the lining of the uterus and the presence of bacteria. The most effective treatment method is to perform surgery to remove the infected uterus. There are other options available if the cat is intended for breeding, but these are not as reliable. If prompt diagnosis and administration of treatment are given, prognosis is usually good.

If the infection is left, it has the potential to spread into the bloodstream and cause sepsis which is often fatal.

divider 3 paws

What Is Pyometra in Cats?

Pyometra is a serious and life-threatening infection that occurs in the uterus of cats. In Latin, “pyo” means pus, and “metra” means uterus, so it translates as pus in the uterus. In this condition, the uterus fills with pus produced by bacteria. A pyometra in cats can be open or closed. Open infections involve vaginal discharge leaking out—there is no discharge seen in closed infections. This can be even more dangerous as it can be more difficult to detect. Cats become very sick with a high temperature, reduced appetite, lethargy, and vomiting amongst other things. Treatment can involve antibiotics or surgical removal of the uterus and ovaries. This surgery is called an ovariohysterectomy.

Any cat that has not been neutered can develop a pyometra. It is more commonly seen in older cats that have had lots of heat cycles without being mated. Pyometra usually occurs when a cat has been in heat in the last month.

Being in “heat” is the term used to describe the period when your cat is ready to mate and produce kittens. After the heat cycle finishes, there is a big shift in the circulating hormones which makes it easier for bacteria to establish an infection in the uterus. Most cats have a good prognosis if the problem is identified promptly and they receive treatment straight away. If left untreated, pyometra can have fatal consequences. Pyometra is a medical emergency and if you are suspicious your cat may have a pyometra, you need to go to a vet immediately. Prevention of pyometra is easily done by spaying cats.

Photo Credit Lee Charlie, Shutterstock

What Are the Signs of Pyometra in Cats?

Clinical signs displayed by a cat with pyometra firstly depend on whether the cat’s cervix (the entrance to the uterus) is open or closed. Signs are often more obvious when the cervix is open as owners will see discharge leaking out of the vagina, however, a closed infection can be more serious as the infection is trapped inside the body and has no route of exit.

Typical signs of pyometra in the cat include:
  • Creamy or blood-tinged vaginal discharge
  • Reduced appetite
  • Lethargic
  • Increased water intake
  • Increased urination
  • Pain reaction when touched on the back or stomach
  • Fever
  • Vomiting
  • Diarrhea
  • Pale gums
  • Weakness
  • Collapse

Consulting a veterinarian is recommended for the best course of action.

If you need to speak with a vet but can't get to one, head over to PangoVet. It's an online service where you can talk to a vet online and get the advice you need for your pet — all at an affordable price!

PangoVet_Mention-in-Content for PangoVet2 save money

What Are the Causes of Pyometra in Cats?

The initial cause of pyometra is hormonal changes making the uterus more susceptible to infections. It usually occurs in older female cats that have not been neutered and have never had kittens. This happens because when a cat is in heat, they experience hormonal changes that cause the uterine walls to thicken in preparation for pregnancy. If the uterus wall repeatedly thickens with no implantation of a pregnancy, cysts develop.

When these cysts burst, they release fluid that facilitates the growth of bacteria. While the cat is in heat, her cervix is open to allow for sperm to swim into the vagina if she is mated. Usually, the white blood cells of the cat’s immune system are stopped from entering the uterus while the cat is in heat. This is to allow the sperm to enter without being identified and destroyed by the white blood cells, however, it also prevents them from acting against bacteria. This means bacteria can enter the uterus and multiply rapidly. As the bacteria grow, the pus is released and a pyometra occurs. When the uterus is full of bacteria and pus, there are toxins released. These toxins can enter the bloodstream and cause sepsis.

The bacteria usually involved in pyometra is E. Coli. This bacterium is spread from the vagina into the uterus. This is facilitated by the cervix being open and soft during the heat cycle. A combination of these different things means the chances of infection are high at this time.

Some cats may develop something called a stump pyometra This occurs when an infection develops in the stump of tissue that has been left behind after a neutering procedure. When a cat is spayed, the reproductive tract is removed from the ovaries to the uterus. The infection develops in the small piece of tissue left behind once the surgery has been completed. This is extremely uncommon in cats.

cat in heat
Photo Credit: Faroe, Shutterstock

Diagnosis of Pyometra in Cats

A vet will take a detailed history from you and perform a thorough clinical exam. They will need to know if your cat has been neutered and if they have been mated recently (if this information is known by the owner).

All un-neutered females showing any of the clinical signs above should be investigated for having a pyometra as it can be difficult to spot if a closed infection is present. Diagnostic tests that a vet may perform include routine blood tests, urinalysis, X-rays of the abdomen, and an ultrasound scan of the abdomen. The vet may take a sample of any vaginal discharge present to be examined.

How Do I Care for a Cat with Pyometra?

The most common treatment for pyometra is surgical removal of the whole uterus and the ovaries too. This removes the source of the infection completely. On some occasions, other treatment options can be offered as well as surgery. These options have a lower success rate than surgery and more risks are involved. It is usually owners of breeding cats that will ask for these as they want to breed from their cat in the future.

One option is the use of antibiotics to fight the bacteria. Another option is using prostaglandins. These are hormones that cause uterine contractions and open up the cervix. This helps expel some of the pus in the uterus. These two options are often used in conjunction with each other.

Other management such as supportive treatment like intravenous fluid therapy will also be used.

divider 3 paws

Frequently Asked Questions

What happens if pyometra is left untreated?

If the pyometra infection is left untreated, it is likely your cat will become very sick. The chances of the infection resolving on its own are slim. The bacteria can produce toxins and the toxins can travel from the uterus into the bloodstream, this causes toxic shock syndrome and can be fatal. If the cat does not receive any treatment in the case of a closed pyometra, the uterus can rupture causing septic peritonitis where the abdomen is filled with pus. This is almost always fatal.

sad-cat-with-green-eyes-lies-at-home
Image Credit: Julia Cherk, Shutterstock

Can pyometra in cats be prevented?

It is possible to prevent the occurrence of pyometra infection by spaying your cat before the infection has developed. An ovariohysterectomy is recommended as this involves the removal of both the ovaries and the uterus. If the owner wants to breed their cat, they should be bred at an appropriate age to minimize the risk of pyometra developing.

How long can a cat live with pyometra?

Once the infection has become established, if the cat does not receive prompt treatment, the cat will deteriorate very quickly. It doesn’t take much time for pyometra to kill a cat. The infection can be fatal within a few days. Closed pyometra infections will generally be more severe and affect the cat quickly as the pus is trapped inside the uterus and has no way to be expelled.

divider 3 paws

Conclusion

Pyometra in cats is a potentially fatal condition that occurs when a bacterial infection becomes established in your cat’s uterus. It is usually seen in unspayed middle-aged or older female cats. The gold standard of treatment is an ovariohysterectomy to remove the ovaries and uterus.

This usually has a positive outcome if it is carried out promptly. It is a medical emergency and if you suspect your cat has pyometra, you must go to a vet immediately.


Featured Photo Credit: Sergey Nivens, Shutterstock

Want content like this delivered to you?

Sign Up For Our Newsletter

News, insights, expert advice, and everything cat

* By submitting, you agree to our Terms & Conditions and Privacy & Cookies Policy.




How useful was this post?

Click on a star to rate (you can leave written feedback after clicking submit)

Help us improve Catster for pet parents!

Your feedback really matters.

What did you like about this post? Also how can we improve it?

Join the conversation

Leave a Reply

You’re very welcome to leave a comment or question. Please know that all comments must meet our community guidelines, and your email address will NOT be published. Let’s have a positive and constructive conversation.


Catster's Digital Magazine is Back!

Vet-approved health & behavior advice

Real cat stories & community features

Chatting With Sally About Mission Meow & Helping Cat Rescue Organizations Collaborate | Chatty Cattys, Episode 24

In this episode of Catster’s podcast, Chatty Cattys, Nicole and Dr. Karyn sit down with Sally Williams, the founder of Mission Meow, for...

Vets Urge Owners: Don’t Ignore Sweet Smell Coming From Cats

Cats are not particularly known for having a pleasant aroma. The occasional whiff of fishy cat breath and that unmistakable post-litter-box scent simply...

“A Cat Spay Costs How Much???”

America has a kitten problem. Every day, thousands of cats and kittens are abandoned, surrendered, or discarded. Those who are lucky enough to...

Ask Dr. Paola – Help! My Cat Is Seeking My Attention! (June 15, 2026)

Welcome to our “Ask Dr. Paola” series, where every Monday we bring expert advice straight from Dr. Paola Cuevas (MVZ) to help our...

More related

Maine Coon Kittens for Sale in Colorado: Breeders List 2026

Catster advocates for adopting before shopping, though we fully understand there are many reasons for seeking a breeder. So, we encourage it to...

The Harsh Reality of Life with 10 Pets Part 2: Hairballs, Cat Litter & Fur on EVERYTHING

Hi, I’m Dr. Karyn! Read my introduction to learn more about me and meet my five hilarious cats: Clutch, Cyril, Alex, Zelda, and...

Can FIV+ Cats Live With Other Cats? Our Vet Explains the Science

Feline immunodeficiency virus (FIV) is a cause of an infectious disease of cats. It is similar to HIV (human immunodeficiency virus) in people,...

Catster Photo Contest: Cats of the Week Winners (January 22, 2026)

Every week our team gets the privilege of sorting through our readers photos to choose what cats will win this weeks contest! See...

Keep reading

Applaws Limited Ingredient Wet Cat Food Review 2026: How I Supplemented My Cats Diet

Any dedicated cat owner likely knows that their house cat does not drink enough water. Whether they were told by their vet, noticed the market explosion of cat water fountains, or simply observed that their cat’s water dish rarely needs...

Applaws Limited Ingredient Wet Food Review - featured image

Why Don’t Cats Make Eye Contact With Other Cats? 4 Vet-Reviewed Reasons

A cat’s eyes are big and enchanting, but did you know that they’re also incredibly expressive? If you’ve just adopted a cat, you might need time to understand what your pet is trying to say with their eyes. But seasoned...

two cats looking at each other

Are Geckos Poisonous to Cats? Vet-Reviewed Dangers & FAQ

Geckos are not venomous or poisonous to cats and dogs, but they can carry a liver fluke, the trematode parasite Platynosomum fastosum, which can potentially cause serious illness. The condition that it causes is sometimes called “lizard poisoning.” Read on...

leopard gecko

Is Catnip Safe for Kittens? Vet-Reviewed Facts & FAQ

In a way, catnip is as much a treat for doting pet parents as it is for their feline family members. We may not get the same euphoric benefits, but it feels good to know we can offer an extra-satisfying...

Catster_Is Catnip Safe for Kittens

Can Cats Eat Scrambled Eggs? Vet-Verified Nutrition Facts & Info

There’s no better breakfast than some nicely cooked scrambled eggs and a couple of slices of toast. It’s simple, delicious, and nutritious. So, what’s the harm in sharing your favorite breakfast with your furry feline companion? Can your cat eat...

Can Cats Eat Scrambled Eggs

Your Cat Doesn’t Like Catnip? 6 Vet-Approved Alternatives

Not all cats are reactive to catnip. And sometimes, you might not like your cat quite as much when they are on the catnip high. Some can be very hyperactive and even aggressive. So for whatever reason you’re looking for...

Closeup of a cat eating catnip

Is There Mercury in Cat Food? Vet-Verified Facts & FAQ

As a cat lover, you understand how irresistible fish is to our feline friends. Because we naturally want to feed them the best we can and reward them with their favorite treats, it’s normal to reach for the fish-flavored kibble...

woman reading pet food label

How Long Should You Play With Your Cat? Vet-Verified Facts & Tips

Cats need exercise in order to be at their healthiest. That’s a fact that we’re sure you know if you’re a cat owner, however, you may not always know how long you should be playing with them or even how...

cat playing with owner

Love Cats? So Do We! Join the Catster Community

Stay informed with expert pet care insights delivered straight to your inbox! Discover professional guidance on animal behavior, feeding tips, trusted product picks, and much more.




Sign up for the Catster Email Newsletter

Stay informed with expert pet care insights delivered straight to your inbox! Discover professional guidance on animal behavior, feeding tips, trusted product picks, and much more.