Catster is reader-supported. When you buy via links on our site, we may earn an affiliate commission at no cost to you. Learn more.

Depression in Cats: Our Vet Answers Signs, Causes & Treatments

Written by: Dr. Paola Cuevas MVZ (Vet)

Last Updated on February 23, 2024 by Catster Editorial Team

sad looking cat lying on a table

Depression in Cats: Our Vet Answers Signs, Causes & Treatments


Dr. Paola Cuevas Photo


Dr. Paola Cuevas

MVZ (Veterinarian)

The information is current and up-to-date in accordance with the latest veterinarian research.

Learn more »

Clinical depression is a medically recognized and fairly common mental health disease of humans. Feelings of sadness and behavioral changes such as lack of motivation to perform regular activities, or disruption of sleeping patterns are some of the signs of this disease. Depression is considered a multifactorial disease. Sometimes depression is caused by a clear emotional trigger such as the separation or loss of a loved one, financial difficulties, etc. Clinical depression can be also caused by chemical imbalances in the brain. What is certain, is that depression in humans can be easily diagnosed due to our ability to verbally express our feelings.

Behavioral changes similar to those experienced by humans with diagnosed clinical depression are the reason why some cat owners think their cat is suffering from depression.

3 cat face divider

Can My Cat Suffer from Depression?

Cats, just like any other animals, are sentient beings and can suffer from mood disorders. Because cats can not express themselves verbally, it is wiser to avoid evaluating them using humanized adjectives or characteristics and instead focus on evaluating them from a more cat-friendly perspective. This will help you better understand and provide the needed solutions for your beloved cat’s “depression”.

sad looking cat lying down
Image Credit: pasja1000, Pixabay

What Are the Signs of “Depression” in Cats?

  • Loss of appetite
  • Activity levels notably decreased
  • Loss of interest in their favorite toys
  • Avoiding owner
  • Abnormal aggressive behavior such as hissing or biting
  • Change in sleeping patterns
  • Change in cat litter box usage
  • Aberrant, self-mutilating behaviors such as biting, pulling hairs out, or excessive licking of paws

It is common for concerned cat owners to assume their cats are suffering from depression upon observation of one or more of these behavioral changes in their cat. However, all of these signs can have several different causes. To better help our beloved furry friends, we need to collect as much information as possible. This will allow us to have a clearer idea of what is going on.

It is very important to address the issue as soon as possible for two reasons:
  • If the issue is behavioral: It is way easier to address the problem and take actions to correct and change the behavior before the issue of concern turns into a habit. The faster we respond, the less habituation of the specific behavior and the easier it will be to work towards eliminating them.
  • If the sign is due to a medical condition: There are greater chances for successful treatment and recovery when the cause of the disease is found earlier. Medical issues tend to complicate over time, or, in the worst-case scenario, in a matter of hours.

What Can I Do If My Cat Shows “Signs of Depression”?

Once we identify that the cat shows any of the mentioned signs, it is important to start gathering information systematically. Cats do not speak about their emotions, but what is certain is that the change of behavior has a cause, and we should make an investigation of what is going on.

3 cat divider

A Guide to Gathering Relevant Information

The Environment:

Identify if there is any change in the environment that happened just before or around the time when your cat’s behavior started changing.

Here are some examples:
  • Your cat has reduced or lost appetite. Has there been a change in the cat food brand, the plate, the placement of the plate, or anything you can identify as different from before?
  • Your cat is refusing to use the litter box. Has there been any change in the box, the litter brand, the placement of the box, or the frequency of cleaning it?

Cats are known to be creatures of habit, and sometimes the smallest changes in the environment can cause behavioral changes in your cat.

Yourself or Any Other Member of the Family:

You notice your cat has suddenly been presenting avoidance behavior towards you. Try to identify if you have changed something in yourself. You are one of the most important parts of your cat’s social environment and although cats are considered to be very independent pets, your behavior has effects on them.

Have you changed your perfume? Are you going through some stressful situation? Have your hours at home changed? Is there a new member in the family or a friend visiting more often than before?

Cats tend to be independent creatures that feel safe with their habitual routines. Small changes in their social environment and routines can cause them anxiety. Anxiety is very often the reason behind behavioral changes in cats.

cat lying on the wooden floor beside litter box
Image Credit: Tanya Plotnikova, Shutterstock

Other Cats:

If you have more than one cat it is always important to evaluate the social interactions and structure between the members of the group. In the case where one of your cats has a reduced appetite and seems to be losing weight, chances are that he is being displaced by one of the other cats. Having multiple feeding stations on opposite sides of the room might solve this problem.

If one of your cats is urinating outside the litter box, chances are other cats are also claiming the box as their property or territory and displacing them. In this case, providing multiple litter boxes could be the solution.

If you have more than one cat in your home it is very important to provide an environment that allows the healthy socialization of the cats. Anxiety and chronic stress can have a very negative impact on a cat’s behavior and health; aberrant self-mutilating behaviors can sometimes be tracked right back to anxiety.

When having a multiple cat household it is always recommended to provide a “safe space” for each cat. Cats prefer higher-up spaces that provide a sense of security and protection for hiding spots. Providing a comfortable and easy to access place for each cat to have a safe place and their “own” territory might do wonders in reducing anxiety in the cats. The Hepper Pet Pod Bed checks all those boxes.

cat paw divider

Should We Visit the Veterinarian?

If the cat’s behavioral changes or anxiety were caused by any changes in the routine the social or environmental factors, the cat’s behavior should return to normal with a few days, resuming habitual routines and “normality”. However, it is always a good practice to visit your veterinarian.

If you can not identify any change in the routines, the social, or physical environment, it is very important to visit your veterinarian as soon as possible. All the signs that we listed and that are claimed to be signs of “depression in cats” are non-specific and could be due to an underlying health issue. Loss of appetite can be caused by something as simple as a small injury in the mouth or by multiple gastrointestinal problems ranging from gastritis to cancers. As well, kidney disease presents with loss of appetite and changes in litter box usage.

As a general rule it is better to visit the veterinarian sooner rather than later, because while some diseases have a slower course, others complicate within a matter of a day or two such as in the case of urethral obstructions in male cats.

cat is being checked by a vet
Image Credit: Maria Sbytova, Shutterstock

How Does the Veterinarian Get an Appropriate Diagnosis?

It is always recommended to provide your veterinarian with all the information you have gathered from your cat’s case.

These are some useful questions to guide you with the information you should provide:
  • What is the approximate age of your cat?
  • How long have you been “his human” (time of ownership)?
  • What are the signs of concern you have noticed in your cat?
  • When did the signs start?
  • Did you notice any change in the physical or social environment of the cat?
  • Has there been any change in your routines? For example, a new job changes the normal times you are around home.
  • Do you have other cats in the same household? And if yes, please specify their sex and other relative information.

By bringing all this information ready with you will help the veterinarian to better understand the case and general situation, adding to better diagnosis and potentially saving you some money. In some cases, differentiating anxiety from other very serious medical conditions such as infections or tumors involving the nervous system is done by elimination. This translates into your veterinarian having enough information that might save you from paying for extra diagnostic tests such as biopsies, X-rays, or even MRIs. Cats never behave the same in the clinic as they do in their home environment, so your behavioral observation is of great value for the clinical history.

3 cat divider

Testing Toward Diagnosis

After understanding the specifics of the case’s history, your veterinarian will proceed to perform a complete physical examination of the cat. After completing the physical examination, the veterinarian will collect a biological sample of your cat’s blood, and maybe also urine or fecal samples.  If more information is needed your veterinarian might also use some diagnostic imaging such as X-rays, ultrasounds, or even an MRI.

After performing the necessary tests and having an appropriate diagnosis of what is causing your cat’s unusual behavior, your veterinarian can address any medical condition such as infections, injury, or pain with appropriate treatments.

Pain in cats is commonly confused by owners with what they describe as “depression.” For this reason, it is always recommended to bring your cat for a medical evaluation if you notice any behavioral change that concerns you.

A Warning Note:

Always follow your veterinarian’s advice and prescriptions, never try to medicate your cat. Keep in mind that several over-the-counter pain management medications for humans are toxic and even lethal for cats.


What Is the Treatment for “Cat Depression”?

a red long-haired tabby cat is being checked up by a vet
Image Credit: Ermolaev Alexander, Shutterstock

Based on the specific case history, the physical examination observations, and the results of the diagnostic test, the veterinarian will develop an appropriate plan to aid your furry friend. If the issue is caused by a medical condition, a variety of treatments ranging from oral medications to surgery will be indicated following the specific medical case.

If the veterinarian has ruled out a disease or underlying medical condition he or she might recommend a consultation with a cat behaviorist and/or start treating your cat for “anxiety”.

The treatment might include the addition of pheromone diffusers to the environment. Pheromone diffusers look like electronic air fresheners, they plug into electrical outlets and required periodic cartridge changes. The cartridge contains synthetic chemicals that mimic naturally occurring pheromones and have a calming effect on the cat’s condition. If this is the case, it is very important to be very specific about what kind of pheromone blend you are looking for. There are a variety of blends in the market; Feliway for example offers good quality products and different compositions for a single pet cat or multiple pet cats sharing a home.

If your veterinarian suspects that pain is the reason for your cat’s “depression” he might prescribe pain management treatments such as ibuprofen or gabapentin.

In addition, your veterinarian might prescribe your cat anxiolytic medications such as Trazadom, Alprazolam, or Midazolam. In any case, the recommendation is to follow your veterinarian’s advice very specifically with regards to the dosage and frequency of the medication. A good cat owner’s practice is to always keep your cat under observation while under new medical treatments. Contact your doctor immediately if you notice something that concerns you.  Never give your cat any medication without the prescription and advice of a veterinarian as you might be increasing the cat’s risks instead of helping them.

cat + line divider

Final Thoughts

As a responsible cat owner, the best you can do for your cat is to understand that yes, when a cat’s behavior changes, there is “something going on” that needs careful evaluation and addressing. You can provide the best value by learning to note these behavioral changes, collecting all relevant information, and taking your cat to a veterinarian’s consultation as soon as possible to rule out any dangerous underlying condition.

Featured Image Credit: avi_acl, Pixabay

Get Catster in your inbox!

Stay informed! Get tips and exclusive deals.
Catster Editors Choice Badge
Shopping Cart


© Pangolia Pte. Ltd. All rights reserved.