Get

In Your Inbox

Catster is reader-supported. When you buy via links on our site, we may earn an affiliate commission at no cost to you. Learn more.

Domestic Shorthair Cat Health Problems: 15 Vet-Verified Issues

Share

Catster_Health Problems of Domestic Shorthair

Domestic shorthair cats are the perfect pet for people who want a small, easy-to-care-for animal that doesn’t require a lot of exercise. These cats have a sturdy build and average weight of around 6 to 8 pounds, making them the perfect size for households with kids or small dogs. They come in a variety of colors and patterns, making them attractive additions to any home.

Domestic shorthairs are a popular choice as pets, but they come with their own set of health problems. These cats can suffer from a number of conditions, most of which are common to other cats and some that are specific to domestic shorthairs.

While there is no one answer to preventing all of these problems, taking care of your cat’s diet and lifestyle can go a long way in helping keep them healthy. Shorthair cats, like all cats, require routine veterinary care to maintain their health.

divider 3 paws

The 15 Domestic Shorthair Cat Health Problems

1. Inflammatory Bowel Disease (IBD)

Inflammatory bowel disease IBD in cats can manifest as vomiting, diarrhea, loose stools, and weight loss. IBD can be diagnosed with intestinal biopsies or advanced imaging such as abdominal ultrasound. Treatment may include steroids and switching to a bland gastrointestinal diet.

cat being observed by a female veterinarian
Image By: David Herraez Calzada, Shutterstock

2. Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy is a heart disease that is caused by an abnormal thickening of the heart muscle. This thickening can prevent the heart from filling with blood properly and can lead to heart failure or clot formation. Domestic shorthair cats are particularly prone to this disease, and it often causes death in these cats.

Signs of hypertrophic cardiomyopathy include shortness of breath, rapid breathing, and coughing. Treatment for the disease includes medication and, in some cases, surgery.


3. Obesity

A domestic shorthair cat is at risk for obesity if its diet is not properly monitored. Overfeeding and giving your cat access to an excessive number of snacks can lead to obesity. Cats that are overweight are at an increased risk of developing diabetes, heart disease, and joint problems. A diet that is high in protein and low in carbohydrates can help reduce the likelihood of a cat becoming obese. We suggest speaking to a vet for advice on the best diet for your cat if you are concerned about their weight.

If you need to speak with a vet but can't get to one, head over to PangoVet. It's an online service where you can talk to a vet online and get the advice you need for your pet — all at an affordable price!

Preventative wellness PGV mention keep cat healthy Preventative wellness PGV mention keep cat healthy mobile

4. Dental Disease

Dental disease in domestic shorthair cats is most commonly caused by an accumulation of plaque and tartar on the teeth. This can lead to inflammation of the gums (gingivitis) and/or infection of the tooth roots (endodontic disease). Dental disease can also cause pain, difficulty eating, and bad breath.

Treatment may include dental cleaning and extractions under anesthesia, antibiotics if an infection is present, and/or oral medications to reduce inflammation and pain.


5. Infections Preventable by Vaccines

A domestic shorthair cat is at risk for a vaccine-preventable infection if it is not vaccinated. The most common infections in unvaccinated cats are feline herpesvirus (FHV), calicivirus (FCV), and feline panleukopenia virus (FPV). These viruses can cause severe respiratory disease, gastrointestinal disease, and neurologic disease, respectively.

Your cat must be vaccinated against the infection to help protect it from becoming ill.

cat vaccination
Image By: bmf-foto.de, Shutterstock

6. Parasites

The most common parasites of domestic shorthaired cats are roundworms, tapeworms, and fleas. All of these parasites can cause serious health problems in cats if not treated. Roundworms can cause intestinal blockages and death, tapeworms can cause weight loss and malnutrition, and fleas can cause skin infections and anemia.

Cats should be routinely dewormed and given monthly flea preventatives to protect them from these parasites.


7. Blood Clots in the Arteries

Arterial thromboembolism is a condition that can affect domestic shorthair cats. The condition is caused by a blood clot that becomes lodged in an artery, preventing blood from flowing to the rest of the body. This can lead to several serious health problems, including tissue damage, heart attack, stroke, and even death.

Arterial thromboembolism can be treated with medications that dissolve the clot or prevent it from forming.

sick cat lying on blanket
Image By: one photo, Shutterstock

8. Feline Lower Urinary Tract Diseases

The term “feline lower urinary tract disease” (FLUTD) refers to a variety of disorders that can affect a cat’s urinary system. These diseases can cause inflammation and irritation in the bladder and urethra, leading to signs such as straining to urinate, blood in the urine, and increased frequency of urination.

FLUTD can be caused by a number of factors, including infection, crystals or stones in the urinary tract, and tumors. Domestic shorthair cats are possibly more prone to developing feline lower urinary tract diseases (FLUTD) than other breeds of cats.


9. Renal Failure

Renal failure (RF) is a common and eventually fatal condition in cats. The kidneys are responsible for filtering toxins and waste products from the blood and excreting them in the urine. When the kidneys fail, these toxins can build up in the body, leading to a number of serious health problems.

Domestic shorthair cats are thought to possibly be more prone to RF, likely due to their genes. Renal failure in domestic shorthair cats is often the result of another underlying disease process, such as infection, inflammation, or cancer. When the kidneys fail, they can no longer remove wastes and toxins from the blood, which can cause a variety of serious health problems.

Treatment for renal failure depends on the underlying cause and may include medications, diet changes, and/or dialysis.

yellow sad sick cat
Image Credit: Nikolay Bassov, Shutterstock

10. Hyperthyroidism

Hyperthyroidism is a condition that affects cats and is caused by an overactive thyroid gland. This condition results in an increase in the cat’s metabolism, which can cause a wide range of signs, including weight loss, increased appetite, increased heart rate, hyperactivity, and restlessness

Treatment for hyperthyroidism usually involves medications to control the thyroid hormone levels, as well as dietary changes and/or surgery to remove the overactive thyroid gland. Domestic shorthair cats may be more prone to hyperthyroidism, and early diagnosis and treatment are essential for the best possible outcome.


11. Diabetes Mellitus

Diabetes mellitus is a chronic disease in cats that is caused by a deficiency in the hormone insulin. Without insulin, the body cannot use glucose (sugar) for energy, and the blood sugar level becomes too high. A high blood sugar level can damage many parts of the body, including the eyes, kidneys, nerves, and blood vessels.

A domestic shorthair cat that has diabetes will have an increased blood sugar level. This is a result of the body not being able to produce enough insulin or the body not being able to use the insulin properly. When the blood sugar level is high, the cat will experience symptoms such as excessive thirst and urination, weight loss, and poor coat condition.

cat thin
Image Credit: Hanish, Pixabay

12. Atopy

Domestic shorthair cats are possibly more prone to atopy, which is a hypersensitivity disorder of the skin. This means that they are more likely to suffer from allergies and other skin problems. Signs of atopy can include scratching, licking, and chewing the skin, as well as hair loss.

Treatment for atopy usually includes medications such as antibiotics to clear up secondary infections, antihistamines, steroids, anti-inflammatory medications, or other topical creams or ointments for the skin, as well as environmental changes like reducing exposure to allergens.


13. Food allergy

Protein sources are the most common cause of food allergies in cats. Proteins such as fish, beef, and chicken are common offenders. Signs of food allergies may include vomiting, diarrhea, excessive scratching, and skin infections. Food allergies can be treated by switching your cat to a novel protein diet. Food allergies are diagnosed with a strict elimination diet food trial for at least 8–12 weeks.

American shorthair cat eating
Image Credit: Apicha Bas, Shutterstock

14. Osteoarthritis

Osteoarthritis is more likely to affect older cats. OA is a chronic degenerative disease resulting in bony changes that can cause pain and discomfort for your cat. Signs of osteoarthritis may include lameness, limping, no longer jumping up on surfaces, or not using the litter box. Your veterinarian can use X-rays to diagnose OA and prescribe appropriate medications to keep your cat comfortable.


15. Pancreatitis

Pancreatitis is inflammation of the pancreas and, subsequently, intestines, usually due to your cat consuming a meal or food that is very high in fats. Some cats will only require some medications from the vet, while others may need to be hospitalized.

vet checking a white cat's face
Image Credit: MakeStory Studio, Shutterstock

divider 3 paws

Conclusion

In conclusion, domestic shorthair cats are susceptible to a number of health problems. These health problems can range from minor to life-threatening. It is important that cat owners are aware of these health problems and take steps to protect their cats from them. By understanding these conditions and taking measures to prevent or treat them, you can help keep your precious cat healthy and over a long and happy life.


Featured Image Credit: Natata, Shutterstock

Want content like this delivered to you?

Sign Up For Our Newsletter

News, insights, expert advice, and everything cat

* By submitting, you agree to our Terms & Conditions and Privacy & Cookies Policy.




How useful was this post?

Click on a star to rate (you can leave written feedback after clicking submit)

Help us improve Catster for pet parents!

Your feedback really matters.

What did you like about this post? Also how can we improve it?

Join the conversation

Leave a Reply

You’re very welcome to leave a comment or question. Please know that all comments must meet our community guidelines, and your email address will NOT be published. Let’s have a positive and constructive conversation.


Talk With A Vet Online

Peace of mind,
anywhere, anytime

Affordable vet advice

Welcome to Coastal Cats & Critters

As much as we all love cats, we also know that in many parts of the country (and the world), the problem of...

Ask Dr. Paola – Help! My Cat Suddenly Has Dandruff! (March 30, 2026)

Welcome to our “Ask Dr. Paola” series, where every Monday we bring expert advice straight from Dr. Paola Cuevas (MVZ) to help our...

Your Cat Keeps Vomiting After Eating: Here’s What’s Going On

Cats vomit. It’s one of the less glamorous facts of life with a feline, and most cat owners have cleaned up more than...

Ask Dr. Paola – Help! My Cat Gets Diarrhea from Wet Food! (March 23, 2026)

Welcome to our “Ask Dr. Paola” series, where every Monday we bring expert advice straight from Dr. Paola Cuevas (MVZ) to help our...

More related

Why Does My Cat Lie on Me? 5 Vet-Reviewed Reasons

We all love to spoil our cats, so they tend to get new toys and tasty treats more often than we do! Seeing...

How to Get the Best Cat Care While on Vacation: 5 Vet-Approved Options to Consider

As much as we’d love to spend every moment possible with our cats, most of us can’t be home 24/7/365. There will come...

Can Cats Get Sunburn? Facts & Safety Tips (Vet Answer)

Cats are often found lounging under the sun, half asleep and basking in its warmth. It’s an image that is equal parts cute...

Why Do Cats Meow & Yowl? 10 Vet-Approved Reasons Behind the Behavior

Your cat’s meow can have many different motives, and there is usually no reason for concern. Cats will meow when they’re hungry, full,...

Keep reading

Can Cats Eat Cookies? Vet-Reviewed Facts & FAQ

While a nibble of your cookie is unlikely to kill your cat, cookies are far from healthy for cats and absolutely should not be fed to your cat regularly. Human sweets are incredibly unhealthy and sometimes very dangerous for cats....

Can Cats Eat Cookies

8 Best Cat Foods for Picky Cats in the UK in 2026: Reviews & Top Picks

Cats generally know what they do and don’t want, and not much can change their minds. This can pertain to where they want to sleep, who they want to cuddle with, and what they want to do during their day....

siamese kitten eating from a stainless bowl

My Cat Ate a Poisoned Mouse! Crucial Vet Reviewed Next Steps

Cats are natural predators. They love to hunt toys, bugs, and small animals if they get the opportunity. Many people have cats as pets for companionship and to help protect their homes from rodents and other pests (like cockroaches). Not...

My Cat Ate a Poisoned Mouse

How to Give a Cat a Flea Bath Without Getting Scratched: 3 Vet-Verified Tips

Any cat can get fleas from time to time, even indoor kitties. If you catch your cat scratching or you spot any signs of fleas, you might wonder if there’s anything you can do at home to help your furry...

bathing cat

How Long Will My Cat Have Diarrhea Once They’ve Been Dewormed? Vet Reviewed Facts

Deworming is a necessary treatment for cats infested with parasites. Parasites are common in cats as they can be spread in various ways, depending on the type. Thankfully, the treatment is safe and effective and only sometimes causes a day...

cat litter box

Do Neutered Cats Spray? Vet-Reviewed Behavior

Cats are wonderful companions, but they do exhibit some quirks that must be dealt with accordingly. One common problem among cat-owning households is spraying, or urine marking. This can be frustrating, smelly, and a real hassle to clean up. While...

black male cat spraying at the garden

5 Possible Reasons Why Your Cat Isn’t Drinking Water: Vet-Reviewed Facts, Remedies & Info

A proverbial thorn in the rose of being a cat parent seems to be worrying if our beloved felines are drinking enough water or not. Indeed, our pets’ drinking habits might worry us at times. Cats should drink water everyday...

bengal cat playing water in the bowl

Will a Cat Get Stressed Out if It Can’t Hide Anywhere? Vet-Approved Facts & FAQ

Have you ever been in a stressful situation you wish you could get away from? When you’re stuck with nowhere to go, stress levels increase, you feel flustered, and you simply don’t know where to turn. Now, imagine the same...

cat hiding

Love Cats? So Do We! Join the Catster Community

Stay informed with expert pet care insights delivered straight to your inbox! Discover professional guidance on animal behavior, feeding tips, trusted product picks, and much more.




Sign up for the Catster Email Newsletter

Stay informed with expert pet care insights delivered straight to your inbox! Discover professional guidance on animal behavior, feeding tips, trusted product picks, and much more.