Comfortis Flea Tablet for Cats - Vet Review in 2026
In this article
Review Summary
Our Final Verdict
If you have a cat, especially one that goes outdoors, you'll want to keep them free of fleas. There are lots of products available when it comes to flea-preventative treatments, including spot-ons, sprays, and tablets. Comfortis is a flea tablet containing Spinosad made by Elanco Animal Health.
Comfortis flea tablets are helpful for cats who develop skin irritation when topical treatments are applied or when other products seem to be less effective. Comfortis is a good choice for cats who have flea-bite allergies. If you can give your cat tablets, Comfortis tablets are very effective at controlling fleas.
Comfortis is a chewable, beef-flavored tablet, making it more palatable for cats. This means some cats will take it as a treat without a fuss. However, many cats might still need a bit of persuasion, and you might end up trying to disguise the tablet in something tasty. Therefore, this might not be the best choice for cats who are tricky to handle or for cats who find it impossible to give pills.
Comfortis Flea Tablet for Cats – A Quick Look
Pros
- Chewable and palatable tablets can be easier to get your cat to take
- Tablets can be crushed or disguised in small amounts of food
- Convenient to use and minimal mess
- Very effective at killing and preventing fleas
- Flea-killing action lasts a month
- Starts working in just 30 minutes
- No chemicals on the skin or fur, so there is no risk to furniture, other pets, or other family members
- There is no risk of the medication washing off as with sprays and spot-on treatments
- Licensed veterinary product is tried, tested, and proven safe and effective
Cons
- Not all cats will take tablets with ease, even when they are palatable
- For treatment to be effective at preventing fleas, a tablet must be given every month
- Current flea infestations may take three months of treatment to resolve
- Quite expensive compared to other flea treatments
- Not safe for use in pregnant or lactating cats
- Only available from your veterinary clinic or with a prescription
Comfortis Flea Tablet for Cats Specifications
| Brand name: | Comfortis |
| Drug name: | Spinosad |
| Manufacturer: | Elanco Animal Health |
| Medication form: | Tablet |
| Target species: | Cats and dogs |
| Type of tablet: | Chew |
| Flavor: | Beef |
| Size of tablets (for cats): | 140 mg, 270 mg, 560 mg |
| Time until effective: | 30 minutes |
| Treatment lasts: | 1 month |
| Suitable for: | Cats over 14 weeks of age |
| Not suitable for: | Cats who are pregnant or lactating |
| Possible side effects: | Vomiting, diarrhea, reduced appetite, lethargy, weight loss |
| Not to be given with: | Off-license doses of Ivermectin |
Beef-Flavored and Chewable Tablets
It's not always easy to give your cat medication, and for some owners, the idea of giving their cat a tablet fills them with dread. Other owners might feel their stress levels rising as they look at the calendar and see the date of their cat's next spot-on approaching. Because Comfortis flea tablets are beef-flavored and chewable, they are more likely to be accepted by your cat as a treat. This takes away the hassle and stress of keeping your cat free from fleas by providing a quick and convenient treatment.
Quick-acting and Lasting Effect
You might think that giving a flea tablet won't kill your cat's fleas as quickly as a topical treatment like a spray or spot-on. However, Comfortis flea tablets for cats effectively kill fleas as early as 30 minutes after treatment. This effect isn't short-lived either, with Comfortis continuing to kill fleas for a month after treatment.
No chemicals to rub off or cause damage
When you apply a spot-on or a spray flea treatment, it can wash off in the rain or get licked off during grooming. It can even rub off on your furniture or upholstery. These chemicals could harm any pets or children who ingest them and cause damage to your furniture. In addition, if some of the treatment has rubbed off, your cat might not receive the necessary dose. The benefit of giving your tablet a cat is that your cat gets the entire dose with no risk of the chemicals going anywhere they shouldn't.
Flea Tablet Price
Although Comfortis flea tablets for cats are at the higher end in terms of price compared to other flea treatments, they do offer good value. Comfortis has a veterinary license, so it is proven to be effective. It's also very quick, and its action continues for a month after treatment.
Tablets Aren't for Everyone
Despite the tablets being palatable, flavored, and chewable, not every cat will take pills. If your cat is a bit of a detective and manages to find medication in even the strongest smelling and tastiest disguise, you might find that Comfortis is not for you. After all, it can only be effective if you can get it into your cat!
FAQ: Comfortis Cat Flea Tablets
Is Comfortis safe for cats?
Comfortis is a safe and effective flea treatment for cats. Like any medication, it can occasionally cause side effects in a small number of patients, but this is uncommon, and the side effects are usually mild. Side effects that your cat might show following treatment with Comfortis include vomiting, diarrhea, lethargy, reduced appetite, or weight loss.
Is Comfortis a good flea treatment for cats?
Yes, Comfortis flea tablets for cats are often easier to give than other tablets due to their beef flavor and chewable form. The tablet is effective from 30 minutes after treatment, and it continues killing fleas for a month.
How do you give a cat Comfortis?
There are three sizes of Comfortis tablets used in cats and these are 140 mg, 270 mg, and 560 mg. The size your cat needs will depend on their body weight. The tablet should be given by mouth once a month and should ideally be given in food.
What the Users Say
We've looked at review sites and forums to provide a summary of what some pet owners think of Comfortis flea tablets.
Here are some of the positive points that we found:
However, we also came across some less positive feedback from users of Comfortis:
Conclusion: Comfortis for Cats Review
In conclusion, Comfortis flea tablets for cats are a fast and effective treatment for fleas if your cat will take them. Their beef flavor and chewable texture are often better accepted than some other tablets. However, not every cat and cat owner will find them an easy option. Comfortis will start killing fleas after just thirty minutes and remains effective for a month, so although it isn't cheap, it's certainly good value for money.
Expert cat care, straight to your inbox
Vet-reviewed advice, behavior tips, and the best of Catster. Free, and you can unsubscribe anytime.
By signing up, you agree to our Terms & Conditions and Privacy & Cookies Policy.
Dr. Joanna Woodnutt BVM BVS (Veterinarian)
Joanna is an experienced veterinarian working in the UK. She has written about pets and their health for many blogs, pet magazines and pet websites and loves to help readers understand their pets through her writing.
She has started her own freelance company so she can help more pet parents than just the one standing in front of her in a consultation room.
She enjoys teaching and educating clients, so a career in writing, public education and pet health is the perfect combination for her.
Join the conversation
Ask a question, share your story, or send private feedback.
