Is a Bengal good with an American shorthair?

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The Purr Machine
Purred: Thu Jan 12, '12 2:18pm PST 
While looking for old cats in my city to adopt I found a purebred Bengal. Patricia is an American shorthair - also purebred. Do you think being different breeds can create a challenge in making them friends if I adopt a Bengal? I have had a mutt before, but Wilbur was not a Bengal mix.